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Antimicrobial Agents and Chemotherapy, September 2000, p. 2530-2533, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Identification of a Plasmid-Borne Chloramphenicol-Florfenicol Resistance Gene in Staphylococcus sciuri

Stefan Schwarz,1,* Christiane Werckenthin,1,2 and Corinna Kehrenberg1

Institut für Tierzucht und Tierverhalten der Bundesforschungsanstalt für Landwirtschaft Braunschweig (FAL), 29223 Celle,1 and Institut für Medizinische Mikrobiologie, Infektions- und Seuchenmedizin, Tierärztliche Fakultät der Ludwig-Maximilians-Universität München, 80539 Munich,2 Germany

Received 18 January 2000/Returned for modification 23 March 2000/Accepted 14 June 2000

The 16.5-kbp plasmid pSCFS1 from Staphylococcus sciuri mediated combined resistance to chloramphenicol and florfenicol. The gene responsible for this resistance property, cfr, was cloned and sequenced. The amino acid sequence of the Cfr protein revealed no homology to known acetyltransferases or efflux proteins involved in chloramphenicol and/or florfenicol resistance or to other proteins whose functions are known.

* Corresponding author. Mailing address: Institut für Tierzucht und Tierverhalten der Bundesforschungsanstalt für Landwirtschaft Braunschweig (FAL), Dörnbergstr. 25-27, 29223 Celle, Germany. Phone: 49-5141-384673 or -384675. Fax: 49-5141-381849. E-mail: schwarz{at}ktf.fal.de.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2530-2533, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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