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Antimicrobial Agents and Chemotherapy, September 2000, p. 2534-2536, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Activities of Imipenem and Cephalosporins against Clonally Related Strains of Escherichia coli Hyperproducing Chromosomal beta -Lactamase and Showing Altered Porin Profiles

L. Martínez-Martínez,1,2,* M. C. Conejo,1 A. Pascual,1,2 S. Hernández-Allés,3 S. Ballesta,1 E. Ramírez de Arellano-Ramos,2 V. J. Benedí,3 and E. J. Perea1,2

Department of Microbiology, School of Medicine,1 and University Hospital V. Macarena,2 Seville, and Area of Microbiology, Department of Biology, and IMEDEA (CSIC-UIB), University of Illes Balears, Palma de Mallorca,3 Spain

Received 15 November 1999/Returned for modification 19 March 2000/Accepted 26 May 2000

Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 µg/ml) and ceftazidime (MICs, 32 to 256 µg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 µg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 µg/ml) and imipenem (MICs, 0.125 to 0.25 µg/ml). Resistance to beta -lactams was related to high-level production of AmpC beta -lactamase and loss of OmpF porin.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Seville, Apdo. 914, 41080 Seville, Spain. Phone: 34-95-5008287. Fax: 34-95-4377413. E-mail: lmartin{at}cica.es.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2534-2536, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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