AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martínez-Martínez, L.
Right arrow Articles by Perea, E. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martínez-Martínez, L.
Right arrow Articles by Perea, E. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, September 2000, p. 2534-2536, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Activities of Imipenem and Cephalosporins against Clonally Related Strains of Escherichia coli Hyperproducing Chromosomal beta -Lactamase and Showing Altered Porin Profiles

L. Martínez-Martínez,1,2,* M. C. Conejo,1 A. Pascual,1,2 S. Hernández-Allés,3 S. Ballesta,1 E. Ramírez de Arellano-Ramos,2 V. J. Benedí,3 and E. J. Perea1,2

Department of Microbiology, School of Medicine,1 and University Hospital V. Macarena,2 Seville, and Area of Microbiology, Department of Biology, and IMEDEA (CSIC-UIB), University of Illes Balears, Palma de Mallorca,3 Spain

Received 15 November 1999/Returned for modification 19 March 2000/Accepted 26 May 2000

Forty clonally related clinical isolates of Escherichia coli from hospitalized patients were resistant to cefoxitin (MICs, >256 µg/ml) and ceftazidime (MICs, 32 to 256 µg/ml) and were intermediate or resistant to cefotaxime (MICs, 16 to 128 µg/ml) but susceptible to both cefepime (MICs, 0.5 to 2 µg/ml) and imipenem (MICs, 0.125 to 0.25 µg/ml). Resistance to beta -lactams was related to high-level production of AmpC beta -lactamase and loss of OmpF porin.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Seville, Apdo. 914, 41080 Seville, Spain. Phone: 34-95-5008287. Fax: 34-95-4377413. E-mail: lmartin{at}cica.es.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2534-2536, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2000 by the American Society for Microbiology. All rights reserved.