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Antimicrobial Agents and Chemotherapy, September 2000, p. 2537-2539, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

TEM-72, a New Extended-Spectrum beta -Lactamase Detected in Proteus mirabilis and Morganella morganii in Italy

Mariagrazia Perilli,1 Bernardetta Segatore,1 Maria Rosaria De Massis,1 Maria Letizia Riccio,2 Ciro Bianchi,3 Alessandro Zollo,3 Gian Maria Rossolini,2 and Gianfranco Amicosante1,*

Dipartimento di Scienze e Tecnologie Biomediche, Cattedra di Enzimologia, Università di L'Aquila, L'Aquila,1 Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Siena,2 and Dipartimento Medico Wyeth-Lederle Italia S.p.A., Aprilia,3 Italy

Received 22 December 1999/Returned for modification 28 March 2000/Accepted 26 May 2000

A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam. Expression of blaTEM-72 in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.

* Corresponding author. Mailing address: Dipartimento di Scienze e Tecnologie Biomediche, Cattedra di Enzimologia, Università di L'Aquila, Località Coppito, Via Vetoio, 67100 L'Aquila, Italy. Phone: 39 0862 433455. Fax: 39 0862 433433. E-mail: amicosante{at}cc.univaq.it.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2537-2539, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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