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Antimicrobial Agents and Chemotherapy, September 2000, p. 2540-2542, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Antimalarial Activities of Aminooxy Compounds

Bradley J. Berger*

Department of Biochemistry, University of Dundee, Dundee, United Kingdom, DD1 5EH

Received 6 March 2000/Returned for modification 7 April 2000/Accepted 30 May 2000

Twenty-three aminooxy compounds have been examined for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum in vitro. Eight of these compounds were found to have 50% inhibitory concentrations less than 10 µM, with the best drugs being canaline (the aminooxy analogue of ornithine) and CGP51905A at 297 ± 23.6 nM and 242 ± 18.8 nM, respectively. Canaline was also assayed in combination with the ornithine decarboxylase inhibitor difluoromethylornithine, and the two drugs were found to be synergistic in antimalarial activity.

* Mailing address: Defence Research Establishment Suffield, P.O. Box 4000 Station Main, Medicine Hat, Alberta, Canada T1A 8K6. Phone: (403) 544-4621. Fax: (403) 544-3388. E-mail: bberger{at}dres.dnd.ca.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2540-2542, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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