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Antimicrobial Agents and Chemotherapy, September 2000, p. 2543-2544, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Susceptibilities of 400 Spanish Isolates of Neisseria gonorrhoeae to Gemifloxacin and 11 Other Antimicrobial Agents

S. Berrón,1 J. A. Vázquez,1 M. J. Giménez,2 L. de la Fuente,1 and L. Aguilar2,*

Spanish National Reference Laboratory for Gonococci, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid,1 and SmithKline Beecham Pharmaceuticals, 28034 Madrid,2 Spain

Received 6 March 2000/Returned for modification 11 May 2000/Accepted 3 June 2000

The in vitro activity of gemifloxacin versus those of 11 other antimicrobial agents against 400 strains of Neisseria gonorrhoeae was determined by microdilution with supplemented GC agar. A total of 37.5% of the strains were beta -lactamase positive. A total of 70 and 6.4% of the beta -lactamase-negative strains exhibited intermediate and high-level penicillin resistance, respectively. Ceftriaxone and gemifloxacin were the most active drugs (MICs at which 90% of isolates are inhibited, 0.01 versus 0.007 µg/ml, respectively), with 100% of strains inhibited by 0.12 µg/ml.

* Corresponding author. Mailing address: Medical Department, SmithKline Beecham Pharmaceuticals, Valle de la Fuenfría, 3, 28034 Madrid, Spain. Phone: 34-91-334 5275. Fax: 34-91-334 5141. E-mail: lorenzo.aguilar-alfaro{at}sb.com.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2543-2544, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Takei, M., Yamaguchi, Y., Fukuda, H., Yasuda, M., Deguchi, T. (2005). Cultivation of Neisseria gonorrhoeae in Liquid Media and Determination of Its In Vitro Susceptibilities to Quinolones. J. Clin. Microbiol. 43: 4321-4327 [Abstract] [Full Text]  


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