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Antimicrobial Agents and Chemotherapy, September 2000, p. 2545-2546, Vol. 44, No. 9
0066-4804/00/$04.00+0

Efficacy of Ampicillin plus Arbekacin in Experimental Rabbit Endocarditis Caused by an Enterococcus faecalis Strain with High-Level Gentamicin Resistance

Vivek Kak,1 Susan M. Donabedian,2 Marcus J. Zervos,2 Reiko Kariyama,3 Hiromi Kumon,3 and Joseph W. Chow1,*

Research and Medical Service, John D. Dingell VA Medical Center, and Wayne State University School of Medicine, Detroit, Michigan 482011; William Beaumont Hospital, Royal Oak, Michigan 480732; and Okayama University Medical School, Okayama 700-8558, Japan3

Received 14 January 2000/Returned for modification 17 March 2000/Accepted 7 June 2000

Enterococcus faecalis LC40 is an ampicillin-susceptible clinical isolate with high-level gentamicin resistance due to the aac(6')-Ie-aph(2")-Ia aminoglycoside resistance gene. The combination of ampicillin plus arbekacin reduced mean bacterial vegetation counts significantly more than ampicillin alone or ampicillin plus gentamicin in a rabbit model of aortic-valve endocarditis caused by E. faecalis LC40.

* Corresponding author. Mailing address: Division of Infectious Diseases, Harper Hospital, 3990 John R, Detroit, MI 48201. Phone: (313) 745-9134. Fax: (313) 993-0302. E-mail: aa2563{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2545-2546, Vol. 44, No. 9
0066-4804/00/$04.00+0


This article has been cited by other articles:

  • Vakulenko, S. B., Mobashery, S. (2003). Versatility of Aminoglycosides and Prospects for Their Future. Clin. Microbiol. Rev. 16: 430-450 [Abstract] [Full Text]  


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