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Antimicrobial Agents and Chemotherapy, September 2000, p. 2567-2568, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vitro Activities of Six Fluoroquinolones against 250 Clinical Isolates of Mycobacterium tuberculosis Susceptible or Resistant to First-Line Antituberculosis Drugs

María Jesús Ruiz-Serrano,* Luis Alcalá, Lucía Martínez, Marisol Díaz, Mercedes Marín, María José González-Abad, and Emilio Bouza

Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario "Gregorio Marañón," Madrid, Spain

Received 2 February 2000/Returned for modification 11 April 2000/Accepted 20 June 2000

Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC90] 1 µg/ml), although ofloxacin also showed good activity, with an MIC90 of 2 µg/ml. Trovafloxacin and gemifloxacin showed lower in vitro activity, with MIC90s of 64 and 8 µg/ml, respectively.

* Corresponding author. Mailing address: Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario "Gregorio Marañón," Doctor Esquerdo, 46, 28007 Madrid, Spain. Phone: (34) 91 586 84 53. Fax: (34) 91 504 49 06. E-mail: mjrfer{at}microb.net.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2567-2568, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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