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Antimicrobial Agents and Chemotherapy, September 2000, p. 2572-2574, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Use of Saliva Specimens for Monitoring Indinavir Therapy in Human Immunodeficiency Virus-Infected Patients

Uwe Wintergerst,1,* M. Kurowski,2 B. Rolinski,3 M. Müller,2 E. Wolf,4 H. Jaeger,4 and B. H. Belohradsky1

Department of Infectious Diseases and Immunology1 and Department of Clinical Chemistry,3 Children's Hospital of the Ludwig-Maximilians University, 80337 Munich, KIS-Curatorium for Immunodeficiencies, 80336 Munich,4 and HIV-Lab, c/o Auguste-Viktoria Hospital, 12157 Berlin,2 Federal Republic of Germany

Received 12 November 1999/Returned for modification 13 February 2000/Accepted 6 June 2000

Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% ± 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen for monitoring of plasma indinavir levels in patients treated with indinavir.

* Corresponding author. Mailing address: Department of Immunology, University Children's Hospital, Lindwurmstraße 4, 80337 Munich 2, Federal Republic of Germany. Phone: 49-89 5160 5318. Fax: 49-89 5160 3964. E-mail: uwe.wintergerst{at}KK-i.med.uni-muenchen.de.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2572-2574, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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Copyright © 2000 by the American Society for Microbiology. All rights reserved.