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Antimicrobial Agents and Chemotherapy, September 2000, p. 2575-2577, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Anti-Toxoplasma Activities of Antiretroviral Drugs and Interactions with Pyrimethamine and Sulfadiazine In Vitro

Francis Derouin* and Maud Santillana-Hayat

Laboratoire de Parasitologie-Mycologie, Faculté de Médecine---Hôpital Saint-Louis, 75006 Paris, France

Received 20 March 2000/Returned for modification 15 May 2000/Accepted 8 June 2000

The anti-Toxoplasma activities of nine antiretroviral drugs were examined in vitro. Nucleoside analogs had no effect on parasite growth, whereas ritonavir and nelfinavir were inhibitory for Toxoplasma, with 50% inhibitory concentrations of 5.4 and 4.0 µg/ml, respectively. None of the antiviral drugs affected the anti-Toxoplasma activity of pyrimethamine or sulfadiazine.

* Corresponding author. Mailing address: Laboratoire de Parasitologie-Mycologie, Faculté de Médecine---Hôpital Saint-Louis, 15 rue de l'Ecole de Médecine, 75006 Paris, France. Phone: 33 1 43 29 65 25. Fax: 33 1 43 29 51 92. E-mail: paracord{at}wanadoo.fr.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2575-2577, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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