Characterization of a Genetic Element Carrying the Macrolide Efflux Gene mef(A) in Streptococcus pneumoniae

doi:10.1128/AAC.44.9.2585-2587.2000

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Antimicrobial Agents and Chemotherapy, September 2000, p. 2585-2587, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of a Genetic Element Carrying the Macrolide Efflux Gene mef(A) in Streptococcus pneumoniae

Maria Santagati,¹^,² Francesco Iannelli,¹ Marco R. Oggioni,¹ Stefania Stefani,² and Gianni Pozzi¹^,^*

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, 53100 Siena,¹ and Dipartimento di Scienze Microbiologiche, Università di Catania, Catania,² Italy

Received 14 February 2000/Returned for modification 21 April 2000/Accepted 27 June 2000

The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was foundto be part of the 7,244-bp chromosomal element Tn1207.1, whichcontained 8 open reading frames. orf2 encodes a resolvase/invertase,and orf5 is a homolog of the macrolide-streptogramin B resistancegene msr(SA).

^* Corresponding author. Mailing address: Microbiologia, Università di Siena, Via Laterina 8, 53100 Siena, Italy. Phone: 39-0577-233430.Fax: 39-0577-233870. E-mail: pozzi{at}unisi.it.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2585-2587, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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