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Antimicrobial Agents and Chemotherapy, September 2000, p. 2585-2587, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of a Genetic Element Carrying the Macrolide Efflux Gene mef(A) in Streptococcus pneumoniae

Maria Santagati,1,2 Francesco Iannelli,1 Marco R. Oggioni,1 Stefania Stefani,2 and Gianni Pozzi1,*

Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, 53100 Siena,1 and Dipartimento di Scienze Microbiologiche, Università di Catania, Catania,2 Italy

Received 14 February 2000/Returned for modification 21 April 2000/Accepted 27 June 2000

The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).

* Corresponding author. Mailing address: Microbiologia, Università di Siena, Via Laterina 8, 53100 Siena, Italy. Phone: 39-0577-233430. Fax: 39-0577-233870. E-mail: pozzi{at}unisi.it.

Antimicrobial Agents and Chemotherapy, September 2000, p. 2585-2587, Vol. 44, No. 9
0066-4804/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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