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Antimicrobial Agents and Chemotherapy, January 2001, p. 145-149, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.145-149.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antimalarial Activities of Peptide Antibiotics Isolated from Fungi

G. Nagaraj,1,dagger M. V. Uma,2 M. S. Shivayogi,1 and Hemalatha Balaram1,*

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064,1 and Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012,2 India

Received 8 May 2000/Returned for modification 13 July 2000/Accepted 12 September 2000

Malaria caused by Plasmodium falciparum is a major public health problem in the developing countries of the world. Clinical treatment of malaria has become complicated due to the occurrence of infections caused by drug resistant parasites. Secondary metabolites from fungi are an attractive source of chemotherapeutic agents. This work reports the isolation and in vitro antiplasmodial activities of peptide antibiotics of fungal origin. The three peptide antibiotics used in this study were efrapeptins, zervamicins, and antiamoebin. The high-performance liquid chromatography-purified peptides were characterized by nuclear magnetic resonance and mass spectral analysis. All three fungal peptides kill P. falciparum in culture with 50% inhibitory concentrations in the micromolar range. A possible mode of action of these peptide antibiotics on P. falciparum is presented.

* Corresponding author. Mailing address: Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore 560 064, India. Phone: 91-80-8462750. Fax: 91-80-8462766. E-mail: hb{at}jncasr.ac.in.

dagger Present address: Bangalore Genei Pvt. Ltd, Peenya, Bangalore 560 058, India.

Antimicrobial Agents and Chemotherapy, January 2001, p. 145-149, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.145-149.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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