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Antimicrobial Agents and Chemotherapy, January 2001, p. 298-300, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.298-300.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

If Taken 1 Hour before Indinavir (IDV), Didanosine Does Not Affect IDV Exposure, despite Persistent Buffering Effects

Mark J. Shelton,1,2,* Haijing Mei,1 Ross G. Hewitt,2,3 and Robin Defrancesco1

Laboratory for Antiviral Research, Department of Pharmacy Practice,1 and Division of Infectious Diseases, School of Medicine,3 State University of New York at Buffalo, and Antiviral Clinical Pharmacology Unit, Immunodeficiency Services Clinic, Erie County Medical Center,2 Buffalo, New York

Received 7 February 2000/Returned for modification 13 June 2000/Accepted 23 September 2000

Concurrent administration of indinavir and didanosine significantly reduces the level of exposure to indinavir, but it is unclear how soon after didanosine administration indinavir may be given safely. We compared indinavir pharmacokinetics and gastric pH in 12 human immunodeficiency virus-positive patients by use of 800 mg of indinavir alone versus 800 mg of indinavir administered 1 h after didanosine administration. Median gastric pH was significantly higher when indinavir was taken after didanosine administration; however, no significant difference in the maximum concentration in plasma or the area under the concentration-time curve from time zero to 8 h was observed. Indinavir may be taken with a light meal 1 h following the administration of 400 mg of didanosine.

* Corresponding author. Mailing address: Departments of Pharmacy Practice and Medicine, 311 Hochstetter Hall, Buffalo, NY 14260. Phone: (716) 898-4194. Fax: (716) 898-3187. E-mail: shelton{at}acsu.buffalo.edu.

Antimicrobial Agents and Chemotherapy, January 2001, p. 298-300, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.298-300.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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