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Antimicrobial Agents and Chemotherapy, January 2001, p. 306-308, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.306-308.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Furazolidone- and Nitrofurantoin-Resistant Helicobacter pylori: Prevalence and Role of Genes Involved in Metronidazole Resistance

Dong H. Kwon,1,* Miae Lee,1 J. J. Kim,2 J. G. Kim,3 F. A. K. El-Zaatari,1 M. S. Osato,1 and D. Y. Graham1,4

Department of Medicine1 and Division of Molecular Virology,4 Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, and Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine,2 and Guro Hospital, Korea University,3 Seoul, Korea

Received 12 May 2000/Returned for modification 20 August 2000/Accepted 3 October 2000

The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant. rdxA, frxA, and fdxB knockouts did not result in furazolidone or nitrofurantoin resistance. These data suggest that furazolidone and nitrofurantoin may be good alternatives to metronidazole for treating H. pylori infection.

* Corresponding author. Mailing address: Rm. 3A-320 (111D), Veterans Affairs Medical Center, 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7276. Fax: (713) 795-4471. E-mail: dkwon{at}bcm.tmc.edu.

Antimicrobial Agents and Chemotherapy, January 2001, p. 306-308, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.306-308.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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