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Antimicrobial Agents and Chemotherapy, January 2001, p. 316-318, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.316-318.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Effective Combination Therapy for Invasive Pneumococcal Pneumonia with Ampicillin and Intravenous Immunoglobulins in a Mouse Model

Laetitia De Hennezel,1 Françoise Ramisse,1 Patrice Binder,2 Gilles Marchal,3 and Jean-Michel Alonso3,*

Centre d'Etudes du Bouchet, 91710 Vert Le Petit,1 Direction Centrale du Service de Santé des Armées, 00459 Armées,2 and Institut Pasteur, 75015 Paris,3 France

Received 22 December 1999/Returned for modification 29 April 2000/Accepted 3 October 2000

Intranasal immunotherapy for Streptococcus pneumoniae invasive pneumonia with polyvalent immunoglobulins (IVIG) was effective in mice against pneumonia but failed to prevent bacteremia. The combination of subcurative doses of IVIG and of ampicillin was fully protective. Such an approach, successfully applied in the preantibiotic era, offers new perspectives for modern therapies.

* Corresponding author. Mailing address: Unite des Neisseria, CNRM, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33-1-45-68-83-30. Fax: 33-1-40-61-30-34. E-mail: jmalonso{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, January 2001, p. 316-318, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.316-318.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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