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Antimicrobial Agents and Chemotherapy, January 2001, p. 319-323, Vol. 45, No. 1
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.1.319-323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Mutation in 23S rRNA Responsible for Resistance to
16-Membered Macrolides and Streptogramins in Streptococcus
pneumoniae
Florence
Depardieu* and
Patrice
Courvalin
Unité des Agents Antibactériens,
Institut Pasteur, 75724 Paris Cedex 15, France
Received 3 July 2000/Returned for modification 11 September
2000/Accepted 11 October 2000
Streptococcus pneumoniae clinical isolate BM4455 was
resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A2062C
(Escherichia coli numbering) mutation in domain V of the
four copies of 23S rRNA.
*
Corresponding author. Mailing address: Unité des
Agents Antibactériens, Institut Pasteur, 25, rue du Docteur Roux,
75724 Paris Cedex 15, France. Phone: (33) (1) 45 68 83 21. Fax: (33) (1) 45 68 83 19. E-mail: fdepard{at}pasteur.fr.
Antimicrobial Agents and Chemotherapy, January 2001, p. 319-323, Vol. 45, No. 1
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.1.319-323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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