Mutation in 23S rRNA Responsible for Resistance to 16-Membered Macrolides and Streptogramins in Streptococcus pneumoniae

doi:10.1128/AAC.45.1.319-323.2001

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Depardieu, F.
	Articles by Courvalin, P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Depardieu, F.
	Articles by Courvalin, P.

Previous Article | Next Article

Antimicrobial Agents and Chemotherapy, January 2001, p. 319-323, Vol. 45, No. 1
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.1.319-323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mutation in 23S rRNA Responsible for Resistance to 16-Membered Macrolides and Streptogramins in Streptococcus pneumoniae

Florence Depardieu^* and Patrice Courvalin

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France

Received 3 July 2000/Returned for modification 11 September 2000/Accepted 11 October 2000

Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusualresistance phenotype was due to an A₂₀₆₂C (Escherichia coli numbering)mutation in domain V of the four copies of 23SrRNA.

^* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25, rue du Docteur Roux, 75724Paris Cedex 15, France. Phone: (33) (1) 45 68 83 21. Fax: (33)(1) 45 68 83 19. E-mail: fdepard{at}pasteur.fr.

This article has been cited by other articles:

Kastrin, T., Gubina, M., Paragi, M., Kolman, J., Cizman, M., Kraigher, A., Ribic, H., Sadowy, E., Hryniewicz, W. (2008). Macrolide resistance among invasive Streptococcus pneumoniae in Slovenia. J Antimicrob Chemother 62: 628-629 [Full Text]
Wierzbowski, A. K., Nichol, K., Laing, N., Hisanaga, T., Nikulin, A., Karlowsky, J. A., Hoban, D. J., Zhanel, G. G. (2007). Macrolide resistance mechanisms among Streptococcus pneumoniae isolated over 6 years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998 2004). J Antimicrob Chemother 60: 733-740 [Abstract] [Full Text]
van der Linden, M., Al-Lahham, A., Haupts, S., Reinert, R. R. (2007). Clonal Spread of mef-Positive Macrolide-Resistant Streptococcus pneumoniae Isolates Causing Invasive Disease in Adults in Germany. Antimicrob. Agents Chemother. 51: 1830-1834 [Abstract] [Full Text]
Cattoir, V., Merabet, L., Legrand, P., Soussy, C.-J., Leclercq, R. (2007). Emergence of a Streptococcus pneumoniae isolate resistant to streptogramins by mutation in ribosomal protein L22 during pristinamycin therapy of pneumococcal pneumonia. J Antimicrob Chemother 59: 1010-1012 [Abstract] [Full Text]
Obert, C. A., Miller, M. L., Montgomery, J., Adamkiewicz, T., Tuomanen, E. I. (2007). Quinupristin-Dalfopristin Nonsusceptibility in Pneumococci from Sickle Cell Disease Patients. Antimicrob. Agents Chemother. 51: 386-389 [Abstract] [Full Text]
Zeng, X., Kong, F., Wang, H., Darbar, A., Gilbert, G. L. (2006). Simultaneous Detection of Nine Antibiotic Resistance-Related Genes in Streptococcus agalactiae Using Multiplex PCR and Reverse Line Blot Hybridization Assay. Antimicrob. Agents Chemother. 50: 204-209 [Abstract] [Full Text]
Malhotra-Kumar, S., Lammens, C., Piessens, J., Goossens, H. (2005). Multiplex PCR for Simultaneous Detection of Macrolide and Tetracycline Resistance Determinants in Streptococci. Antimicrob. Agents Chemother. 49: 4798-4800 [Abstract] [Full Text]
Carsenti-Dellamonica, H., Galimand, M., Vandenbos, F., Pradier, C., Roger, P. M., Dunais, B., Sabah, M., Mancini, G., Dellamonica, P. (2005). In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides. J Antimicrob Chemother 56: 633-642 [Abstract] [Full Text]
Gregory, S. T., Carr, J. F., Rodriguez-Correa, D., Dahlberg, A. E. (2005). Mutational Analysis of 16S and 23S rRNA Genes of Thermus thermophilus. J. Bacteriol. 187: 4804-4812 [Abstract] [Full Text]
Gibreel, A., Kos, V. N., Keelan, M., Trieber, C. A., Levesque, S., Michaud, S., Taylor, D. E. (2005). Macrolide Resistance in Campylobacter jejuni and Campylobacter coli: Molecular Mechanism and Stability of the Resistance Phenotype. Antimicrob. Agents Chemother. 49: 2753-2759 [Abstract] [Full Text]
Reinert, R. R., Reinert, S., van der Linden, M., Cil, M. Y., Al-Lahham, A., Appelbaum, P. (2005). Antimicrobial Susceptibility of Streptococcus pneumoniae in Eight European Countries from 2001 to 2003. Antimicrob. Agents Chemother. 49: 2903-2913 [Abstract] [Full Text]
Davies, T. A., Bush, K., Sahm, D., Evangelista, A. (2005). Predominance of 23S rRNA Mutants among Non-Erm, Non-Mef Macrolide-Resistant Clinical Isolates of Streptococcus pneumoniae Collected in the United States in 1999-2000. Antimicrob. Agents Chemother. 49: 3031-3033 [Abstract] [Full Text]
Kosowska, K., Hoellman, D. B., Lin, G., Clark, C., Credito, K., McGhee, P., Dewasse, B., Bozdogan, B., Shapiro, S., Appelbaum, P. C. (2005). Antipneumococcal Activity of Ceftobiprole, a Novel Broad-Spectrum Cephalosporin. Antimicrob. Agents Chemother. 49: 1932-1942 [Abstract] [Full Text]
Reinert, R. R., Ringelstein, A., van der Linden, M., Cil, M. Y., Al-Lahham, A., Schmitz, F.-J. (2005). Molecular Epidemiology of Macrolide-Resistant Streptococcus pneumoniae Isolates in Europe. J. Clin. Microbiol. 43: 1294-1300 [Abstract] [Full Text]
Farrell, D. J., Morrissey, I., Bakker, S., Buckridge, S., Felmingham, D. (2004). In Vitro Activities of Telithromycin, Linezolid, and Quinupristin-Dalfopristin against Streptococcus pneumoniae with Macrolide Resistance Due to Ribosomal Mutations. Antimicrob. Agents Chemother. 48: 3169-3171 [Abstract] [Full Text]
Petropoulos, A. D., Xaplanteri, M. A., Dinos, G. P., Wilson, D. N., Kalpaxis, D. L. (2004). Polyamines Affect Diversely the Antibiotic Potency: INSIGHT GAINED FROM KINETIC STUDIES OF THE BLASTICIDIN S AND SPIRAMYCIN INTERACTIONS WITH FUNCTIONAL RIBOSOMES. J. Biol. Chem. 279: 26518-26525 [Abstract] [Full Text]
Reinert, R. R. (2004). Clinical efficacy of ketolides in the treatment of respiratory tract infections. J Antimicrob Chemother 53: 918-927 [Abstract] [Full Text]
Cochella, L., Green, R. (2004). Isolation of antibiotic resistance mutations in the rRNA by using an in vitro selection system. Proc. Natl. Acad. Sci. USA 101: 3786-3791 [Abstract] [Full Text]
Pereyre, S., Guyot, C., Renaudin, H., Charron, A., Bebear, C., Bebear, C. M. (2004). In Vitro Selection and Characterization of Resistance to Macrolides and Related Antibiotics in Mycoplasma pneumoniae. Antimicrob. Agents Chemother. 48: 460-465 [Abstract] [Full Text]
Waites, K. B., Jones, K. E., Kim, K. H., Moser, S. A., Johnson, C. N., Hollingshead, S. K., Kang, E.-S., Hong, K. S., Benjamin, W. H. Jr. (2003). Dissemination of Macrolide-Resistant Streptococcus pneumoniae Isolates Containing Both erm(B) and mef(A) in South Korea. J. Clin. Microbiol. 41: 5787-5791 [Abstract] [Full Text]
Walsh, F., Willcock, J., Amyes, S. (2003). High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. J Antimicrob Chemother 52: 345-353 [Abstract] [Full Text]
Montanari, M. P., Cochetti, I., Mingoia, M., Varaldo, P. E. (2003). Phenotypic and Molecular Characterization of Tetracycline- and Erythromycin-Resistant Strains of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 47: 2236-2241 [Abstract] [Full Text]
Reinert, R. R., Wild, A., Appelbaum, P., Lutticken, R., Cil, M. Y., Al-Lahham, A. (2003). Ribosomal Mutations Conferring Resistance to Macrolides in Streptococcus pneumoniae Clinical Strains Isolated in Germany. Antimicrob. Agents Chemother. 47: 2319-2322 [Abstract] [Full Text]
Farrell, D. J., Douthwaite, S., Morrissey, I., Bakker, S., Poehlsgaard, J., Jakobsen, L., Felmingham, D. (2003). Macrolide Resistance by Ribosomal Mutation in Clinical Isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 Study. Antimicrob. Agents Chemother. 47: 1777-1783 [Abstract] [Full Text]
Peric, M., Bozdogan, B., Jacobs, M. R., Appelbaum, P. C. (2003). Effects of an Efflux Mechanism and Ribosomal Mutations on Macrolide Susceptibility of Haemophilus influenzae Clinical Isolates. Antimicrob. Agents Chemother. 47: 1017-1022 [Abstract] [Full Text]
Reinert, R. R., Lutticken, R., Bryskier, A., Al-Lahham, A. (2003). Macrolide-Resistant Streptococcus pneumoniae and Streptococcus pyogenes in the Pediatric Population in Germany during 2000-2001. Antimicrob. Agents Chemother. 47: 489-493 [Abstract] [Full Text]
Montanari, M. P., Mingoia, M., Cochetti, I., Varaldo, P. E. (2003). Phenotypes and Genotypes of Erythromycin-Resistant Pneumococci in Italy. J. Clin. Microbiol. 41: 428-431 [Abstract] [Full Text]
Giovanetti, E., Brenciani, A., Burioni, R., Varaldo, P. E. (2002). A Novel Efflux System in Inducibly Erythromycin-Resistant Strains of Streptococcus pyogenes. Antimicrob. Agents Chemother. 46: 3750-3755 [Abstract] [Full Text]
Leclercq, R., Courvalin, P. (2002). Resistance to Macrolides and Related Antibiotics in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46: 2727-2734 [Full Text]
Kozlov, R. S., Bogdanovitch, T. M., Appelbaum, P. C., Ednie, L., Stratchounski, L. S., Jacobs, M. R., Bozdogan, B. (2002). Antistreptococcal Activity of Telithromycin Compared with Seven Other Drugs in Relation to Macrolide Resistance Mechanisms in Russia. Antimicrob. Agents Chemother. 46: 2963-2968 [Abstract] [Full Text]
Ng, L.-K., Martin, I., Liu, G., Bryden, L. (2002). Mutation in 23S rRNA Associated with Macrolide Resistance in Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 46: 3020-3025 [Abstract] [Full Text]
Prunier, A.-L., Malbruny, B., Tande, D., Picard, B., Leclercq, R. (2002). Clinical Isolates of Staphylococcus aureus with Ribosomal Mutations Conferring Resistance to Macrolides. Antimicrob. Agents Chemother. 46: 3054-3056 [Abstract] [Full Text]
Malbruny, B., Canu, A., Bozdogan, B., Fantin, B., Zarrouk, V., Dutka-Malen, S., Feger, C., Leclercq, R. (2002). Resistance to Quinupristin-Dalfopristin Due to Mutation of L22 Ribosomal Protein in Staphylococcus aureus. Antimicrob. Agents Chemother. 46: 2200-2207 [Abstract] [Full Text]
Malbruny, B., Nagai, K., Coquemont, M., Bozdogan, B., Andrasevic, A. T., Hupkova, H., Leclercq, R., Appelbaum, P. C. (2002). Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations. J Antimicrob Chemother 49: 935-939 [Abstract] [Full Text]
Pihlajamaki, M., Kaijalainen, T., Huovinen, P., Jalava, J., the Finnish Study Group for Antimicrobial Resistan, (2002). Rapid increase in macrolide resistance among penicillin non-susceptible pneumococci in Finland, 1996-2000. J Antimicrob Chemother 49: 785-792 [Abstract] [Full Text]
Pihlajamaki, M., Kataja, J., Seppala, H., Elliot, J., Leinonen, M., Huovinen, P., Jalava, J. (2002). Ribosomal Mutations in Streptococcus pneumoniae Clinical Isolates. Antimicrob. Agents Chemother. 46: 654-658 [Abstract] [Full Text]
Shortridge, V. D., Zhong, P., Cao, Z., Beyer, J. M., Almer, L. S., Ramer, N. C., Doktor, S. Z., Flamm, R. K. (2002). Comparison of In Vitro Activities of ABT-773 and Telithromycin against Macrolide-Susceptible and -Resistant Streptococci and Staphylococci. Antimicrob. Agents Chemother. 46: 783-786 [Abstract] [Full Text]
Musher, D. M., Dowell, M. E., Shortridge, V. D., Flamm, R. K., Jorgensen, J. H., Le Magueres, P., Krause, K. L. (2002). Emergence of Macrolide Resistance during Treatment of Pneumococcal Pneumonia. NEJM 346: 630-631 [Full Text]
Canu, A., Malbruny, B., Coquemont, M., Davies, T. A., Appelbaum, P. C., Leclercq, R. (2002). Diversity of Ribosomal Mutations Conferring Resistance to Macrolides, Clindamycin, Streptogramin, and Telithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46: 125-131 [Abstract] [Full Text]
Farrell, D. J., Morrissey, I., Bakker, S., Felmingham, D. (2001). Detection of macrolide resistance mechanisms in Streptococcus pneumoniae and Streptococcus pyogenes using a multiplex rapid cycle PCR with microwell-format probe hybridization. J Antimicrob Chemother 48: 541-544 [Abstract] [Full Text]
Furneri, P. M., Rappazzo, G., Musumarra, M. P., Di Pietro, P., Catania, L. S., Roccasalva, L. S. (2001). Two New Point Mutations at A2062 Associated with Resistance to 16-Membered Macrolide Antibiotics in Mutant Strains of Mycoplasma hominis. Antimicrob. Agents Chemother. 45: 2958-2960 [Abstract] [Full Text]
Fitoussi, F., Loukil, C., Gros, I., Clermont, O., Mariani, P., Bonacorsi, S., Le Thomas, I., Deforche, D., Bingen, E. (2001). Mechanisms of Macrolide Resistance in Clinical Group B Streptococci Isolated in France. Antimicrob. Agents Chemother. 45: 1889-1891 [Abstract] [Full Text]

Clin. Vaccine Immunol.	Clin. Microbiol. Rev.
J. Clin. Microbiol.	ALL ASM JOURNALS