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Antimicrobial Agents and Chemotherapy, January 2001, p. 319-323, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.319-323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mutation in 23S rRNA Responsible for Resistance to 16-Membered Macrolides and Streptogramins in Streptococcus pneumoniae

Florence Depardieu* and Patrice Courvalin

Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France

Received 3 July 2000/Returned for modification 11 September 2000/Accepted 11 October 2000

Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A2062C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.

* Corresponding author. Mailing address: Unité des Agents Antibactériens, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone: (33) (1) 45 68 83 21. Fax: (33) (1) 45 68 83 19. E-mail: fdepard{at}pasteur.fr.

Antimicrobial Agents and Chemotherapy, January 2001, p. 319-323, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.319-323.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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