In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium Isolates

doi:10.1128/AAC.45.1.327-330.2001

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Antimicrobial Agents and Chemotherapy, January 2001, p. 327-330, Vol. 45, No. 1
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.1.327-330.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Susceptibility Testing Methods for Caspofungin against Aspergillus and Fusarium Isolates

Sevtap Arikan,^* Mario Lozano-Chiu, Victor Paetznick, and John H. Rex

Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas 77030

Received 5 June 2000/Returned for modification 11 July 2000/Accepted 18 October 2000

We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tipsmicroscopically (minimum effective concentration; MEC) in measuringthe in vitro activity of caspofungin against Aspergillus and Fusarium.Caspofungin generated low MICs and MECs against Aspergillus, butnot for Fusarium. While MICs increased inconsistently when theincubation time was prolonged, MEC appeared as a stable and potentiallyrelevant endpoint in testing in vitro caspofunginactivity.

^* Corresponding author. Present address: Hacettepe University Medical School, Department of Microbiology and Clinical Microbiology,06100 Ankara, Turkey. Phone: 90-312-3051562. Fax: 90-312-3115250.E-mail: sarikan{at}metu.edu.tr.

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