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Antimicrobial Agents and Chemotherapy, January 2001, p. 335-338, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.335-338.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Genomic Rearrangement of the mec Regulator Region Mediated by Insertion of IS431 in Methicillin-Resistant Staphylococci

Nobumichi Kobayashi,* Mohammed Mahbub Alam, and Shozo Urasawa

Department of Hygiene, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan

Received 12 May 2000/Returned for modification 15 August 2000/Accepted 2 October 2000

Genomic diversification of the mec regulator region mediated by IS431 was investigated for clinical isolates of methicillin-resistant staphylococci. A single rearranged form of the mecR1 gene due to IS431 insertion was detected in the three staphylococcal species, while another type of mecR1 truncation with IS431 and an IS431 located downstream of mecI were found only in Staphylococcus haemolyticus. Genetic differentiation of IS431 and staphylococcal isolates suggested transmission of mecDNA with IS431-mediated rearrangement among different staphylococcal species.

* Corresponding author. Mailing address: Department of Hygiene, Sapporo Medical University School of Medicine, S-1, W-17, Chuo-ku, Sapporo 060-8556, Japan. Phone: 81-11-611-2111, ext. 2733. Fax: 81-11-612-1660. E-mail: nkobayas{at}sapmed.ac.jp.

Antimicrobial Agents and Chemotherapy, January 2001, p. 335-338, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.335-338.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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