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Antimicrobial Agents and Chemotherapy, January 2001, p. 339-341, Vol. 45, No. 1
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.1.339-341.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Prevalence and Mechanisms of Macrolide Resistance
in Streptococcus pyogenes in Santiago, Chile
E. L.
Palavecino,1,
I.
Riedel,1
X.
Berrios,1
S.
Bajaksouzian,2
D.
Johnson,3
E.
Kaplan,3 and
M.
R.
Jacobs2,*
Laboratory Services and Department of Public
Health, Universidad Catolica, Santiago, Chile1;
Department of Pediatrics, University of Minnesota, Minneapolis,
Minnesota 554553; and Department of
Pathology, Case Western Reserve University, and University
Hospitals of Cleveland, Cleveland, Ohio 441062
Received 7 March 2000/Returned for modification 24 July
2000/Accepted 3 October 2000
Thirty-two macrolide-resistant Streptococcus pyogenes
isolates were found among 594 clinical isolates collected from 1990 to
1998 in Santiago, Chile, for an overall prevalence of 7.2%. Among the
32 resistant isolates, 28 (87.5%) presented the M phenotype and 4 (12.5%) presented the MLSB phenotype. Serotyping and
pulsed-field gel electrophoresis analysis showed genetic diversity
among the resistant isolates.
*
Corresponding author. Mailing address: Department of
Pathology, University Hospitals of Cleveland, 11100 Euclid Ave.,
Cleveland, OH 44106. Phone: (216) 844-3484. Fax: (216) 844-5601. E-mail: mrj6{at}po.cwru.edu.

Present address: Department of Pathology, University Hospitals of
Cleveland, Cleveland, OH
44106.
Antimicrobial Agents and Chemotherapy, January 2001, p. 339-341, Vol. 45, No. 1
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.1.339-341.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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