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Antimicrobial Agents and Chemotherapy, January 2001, p. 342-344, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.342-344.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Identification of an erm(A) Erythromycin Resistance Methylase Gene in Streptococcus pneumoniae Isolated in Greece

George A. Syrogiannopoulos,1,* Ioanna N. Grivea,1 Amelia Tait-Kamradt,2 George D. Katopodis,1 Nicholas G. Beratis,1 Joyce Sutcliffe,2 Peter C. Appelbaum,3 and Todd A. Davies3

Department of Pediatrics, General University Hospital, University of Patras, School of Medicine, Patras, Greece1; Department of Infectious Diseases, Pfizer Global Research and Development, Groton, Connecticut2; and Department of Pathology, The Milton S. Hershey Medical Center, Hershey, Philadelphia, Pennsylvania3

Received 30 June 2000/Returned for modification 21 August 2000/Accepted 12 October 2000

In a serotype 11A clone of erythromycin-resistant pneumococci isolated from young Greek carriers, we identified the nucleotide sequence of erm(A), a methylase gene previously described as erm(TR) in Streptococcus pyogenes. The erm(A) pneumococci were resistant to 14- and 15-member macrolides, inducibly resistant to clindamycin, and susceptible to streptogramin B. To our knowledge, this is the first identification of resistance to erythromycin in S. pneumoniae attributed solely to the carriage of the erm(A) gene.

* Corresponding author. Mailing address: Department of Pediatrics, Division of Infectious Diseases, University of Patras, School of Medicine, 265 00 Rion, Patras, Greece. Phone: 30-61-993948. Fax: 30-61-994533. E-mail: syrogian{at}med.upatras.gr.

Antimicrobial Agents and Chemotherapy, January 2001, p. 342-344, Vol. 45, No. 1
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.1.342-344.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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