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Antimicrobial Agents and Chemotherapy, October 2001, p. 2897-2901, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2897-2901.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antimalarial Drugs Clear Resistant Parasites from Partially Immune Hosts

Pedro Cravo, Richard Culleton, Paul Hunt, David Walliker, and Margaret J. Mackinnon*

Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom

Received 27 February 2001/Returned for modification 24 April 2001/Accepted 14 July 2001

Circumstantial evidence in human malaria suggests that elimination of parasites by drug treatment meets higher success rates in individuals having some background immunity. In this study, using the rodent malaria model Plasmodium chabaudi, we show that drug-resistant parasites can be cleared by drugs when the host is partially immune.

* Corresponding author. Mailing address: Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Rd., Edinburgh EH9 3JT, United Kingdom. Phone: (44) 131 6507706. Fax: (44) 131 6506564. E-mail: m.mackinnon{at}ed.ac.uk.

Antimicrobial Agents and Chemotherapy, October 2001, p. 2897-2901, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2897-2901.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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