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Antimicrobial Agents and Chemotherapy, October 2001, p. 2955-2957, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2955-2957.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Streptococcus pneumoniae Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Clonal Diversity and Appearance of Ciprofloxacin-Resistant Epidemic Clones

Luis Alou,1,2 Mario Ramirez,1,* César García-Rey,3 José Prieto,2 and Hermínia de Lencastre1,4

Molecular Genetics Laboratory, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal1; Microbiology Department, School of Medicine, Universidad Complutense,2 and Medical Department, GlaxoSmithKline Pharmaceuticals,3 Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York4

Received 12 April 2001/Returned for modification 7 June 2001/Accepted 9 July 2001

Analysis of the pulsed-field gel electrophoretic profiles of 82 pneumococcal isolates with reduced susceptibility to ciprofloxacin (RSC) and of 90 co-occurring susceptible isolates indicates a considerable genetic diversity among isolates with RCS and points to a close relation between the two groups. This finding suggests that pneumococci with RCS emerge through independent mutational events.

* Corresponding author. Mailing address: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apartado 127, R. da Qta. Grande 6, Oeiras, Portugal. Phone: 351-21-446 9800. Fax: 351-21-442 8766. E-mail: ramirma{at}itqb.unl.pt.

Antimicrobial Agents and Chemotherapy, October 2001, p. 2955-2957, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2955-2957.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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