AAC
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow An author's correction has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Alou, L.
Right arrow Articles by de Lencastre, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alou, L.
Right arrow Articles by de Lencastre, H.

Antimicrobial Agents and Chemotherapy, October 2001, p. 2955-2957, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2955-2957.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Streptococcus pneumoniae Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Clonal Diversity and Appearance of Ciprofloxacin-Resistant Epidemic Clones

Luis Alou,1,2 Mario Ramirez,1,* César García-Rey,3 José Prieto,2 and Hermínia de Lencastre1,4

Molecular Genetics Laboratory, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal1; Microbiology Department, School of Medicine, Universidad Complutense,2 and Medical Department, GlaxoSmithKline Pharmaceuticals,3 Madrid, Spain; and Laboratory of Microbiology, The Rockefeller University, New York, New York4

Received 12 April 2001/Returned for modification 7 June 2001/Accepted 9 July 2001

Analysis of the pulsed-field gel electrophoretic profiles of 82 pneumococcal isolates with reduced susceptibility to ciprofloxacin (RSC) and of 90 co-occurring susceptible isolates indicates a considerable genetic diversity among isolates with RCS and points to a close relation between the two groups. This finding suggests that pneumococci with RCS emerge through independent mutational events.

* Corresponding author. Mailing address: Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Apartado 127, R. da Qta. Grande 6, Oeiras, Portugal. Phone: 351-21-446 9800. Fax: 351-21-442 8766. E-mail: ramirma{at}itqb.unl.pt.

Antimicrobial Agents and Chemotherapy, October 2001, p. 2955-2957, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2955-2957.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Clin. Vaccine Immunol. Clin. Microbiol. Rev.
J. Clin. Microbiol. ALL ASM JOURNALS

Copyright © 2001 by the American Society for Microbiology. All rights reserved.