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Antimicrobial Agents and Chemotherapy, October 2001, p. 2958-2960, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2958-2960.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Two New Point Mutations at A2062 Associated with Resistance to 16-Membered Macrolide Antibiotics in Mutant Strains of Mycoplasma hominis

Pio Maria Furneri,1,* Giancarlo Rappazzo,2 Maria Pia Musumarra,1 Patrizia Di Pietro,1 Lucrezia S. Catania,1 and Lucia Silvana Roccasalva1

Dipartimento di Scienze Microbiologiche e Scienze Ginecologiche1 and Dipartimento di Biologia Animale,2 Università degli Studi, Catania, Italia

Received 12 March 2001/Returned for modification 17 April 2001/Accepted 20 July 2001

We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.

* Corresponding author. Mailing address: Dipartimento di Scienze Microbiologiche e Scienze Ginecologiche, Università di Catania, Via Androne 81, 95124 Catania, Italy. Phone: 39 095316038. Fax: 39 095312798. E-mail: furneri{at}mbox.unict.it.

Antimicrobial Agents and Chemotherapy, October 2001, p. 2958-2960, Vol. 45, No. 10
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.10.2958-2960.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.