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Antimicrobial Agents and Chemotherapy, November 2001, p. 3014-3020, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3014-3020.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Family of Class 1 Integrons Related to In4 from Tn1696

Sally R. Partridge,1,2 Gavin D. Recchia,1,2,dagger H. W. Stokes,2 and Ruth M. Hall1,*

CSIRO Molecular Science, North Ryde, New South Wales 2113,1 and Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2109,2 Australia

Received 26 March 2001/Returned for modification 11 June 2001/Accepted 5 August 2001

The class 1 integron In28, found in the multidrug resistance transposon Tn1403, was found to be located in the res site of the backbone transposon and is flanked by a 5-bp direct duplication, indicating that it reached this position by transposition. In28 has a backbone structure related to that of In4, but has lost internal sequences, including the sul1 gene, due to an IS6100-mediated deletion. In28 also lacks the partial copy of IS6100 found in In4 and contains different gene cassettes, blaP1, cmlA1, and aadA1. In1, the class 1 integron found in the multidrug resistance plasmid R46, is also located in a putative res site and belongs to the In4 group. In1 has a shorter internal deletion than In28 and has also lost one end. Additional integrons with structures related to In4 were also found in databases, and most of them had also lost either one end or internal regions or both. Tn610 belongs to this group.

* Corresponding author. Mailing address: CSIRO Molecular Science, Sydney Laboratory, PO Box 184, North Ryde, NSW 1670, Australia. Phone: 61-2-9490 5162. Fax: 61-2-9490 5005. E-mail: ruth.hall{at}molsci.csiro.au.

dagger Present address: Freehills Carter Smith Beadle, MLC Centre, Sydney, NSW 2000, Australia.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3014-3020, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3014-3020.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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