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Antimicrobial Agents and Chemotherapy, November 2001, p. 3195-3197, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3195-3197.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

New Model of Oropharyngeal Candidiasis in Mice

Yasuki Kamai,1,* Mikie Kubota,1 Yoko Kamai,2 Tsunemichi Hosokawa,2 Takashi Fukuoka,1 and Scott G. Filler3

Biological Research Laboratories1 and Laboratory Animal Science and Toxicology Research Laboratories,2 Sankyo Co., Ltd., Shinagawa-ku, Tokyo 140-8710, Japan, and Harbor-UCLA Research and Education Institute, Torrance, California 905023

Received 9 February 2001/Returned for modification 6 June 2001/Accepted 3 August 2001

We established a straightforward murine model of oropharyngeal candidiasis. Mice were immunosuppressed with cortisone acetate, anesthetized, and then inoculated by placing cotton wool balls saturated with Candida albicans sublingually for 2 h. A prolonged, reproducible infection was induced. This model may be useful for antifungal screening or pathogenesis studies.

* Corresponding author. Mailing address: Biological Research Laboratories, Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo, 140-8710, Japan. Phone: 81-3-3492-3131. Fax: 81-3-5436-8565. E-mail: ykamai{at}shina.sankyo.co.jp.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3195-3197, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3195-3197.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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