This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shimizu, M.
Right arrow Articles by Tsuchiya, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shimizu, M.
Right arrow Articles by Tsuchiya, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2001, p. 3198-3201, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3198-3201.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Marked Potentiation of Activity of beta -Lactams against Methicillin-Resistant Staphylococcus aureus by Corilagin

Masato Shimizu,1 Sumiko Shiota,1 Tohru Mizushima,1 Hideyuki Ito,2 Tsutomu Hatano,2 Takashi Yoshida,2 and Tomofusa Tsuchiya1,*

Department of Microbiology1 and Department of Pharmacognosy,2 Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan

Received 13 September 2000/Returned for modification 14 February 2001/Accepted 16 July 2001

We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of beta -lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various beta -lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama, 700-8530, Japan. Phone: 81-86-251-7957. Fax: 81-86-251-7957. E-mail: tsuchiya{at}pharm.okayama-u.ac.jp.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3198-3201, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3198-3201.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Shibata, H., Kondo, K., Katsuyama, R., Kawazoe, K., Sato, Y., Murakami, K., Takaishi, Y., Arakaki, N., Higuti, T. (2005). Alkyl Gallates, Intensifiers of {beta}-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49: 549-555 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»