This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guthmiller, J. M.
Right arrow Articles by Tack, B. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guthmiller, J. M.
Right arrow Articles by Tack, B. F.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2001, p. 3216-3219, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3216-3219.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Susceptibilities of Oral Bacteria and Yeast to Mammalian Cathelicidins

Janet M. Guthmiller,1,2,* Kaaren G. Vargas,2,3 Rupasree Srikantha,2 Lori L. Schomberg,2 Paula L. Weistroffer,2 Paul B. McCray Jr.,4 and Brian F. Tack5

Departments of Periodontics1 and Pediatric Dentistry3 and Dows Institute for Dental Research,2 College of Dentistry, and Departments of Pediatrics4 and Microbiology,5 College of Medicine, University of Iowa, Iowa City, Iowa

Received 2 October 2000/Returned for modification 30 April 2001/Accepted 26 July 2001

The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections.

* Corresponding author. Mailing address: Department of Periodontics, College of Dentistry, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-7238. Fax: (319) 335-7239. E-mail: janet-guthmiller{at}uiowa.edu.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3216-3219, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3216-3219.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Bachrach, G., Altman, H., Kolenbrander, P. E., Chalmers, N. I., Gabai-Gutner, M., Mor, A., Friedman, M., Steinberg, D. (2008). Resistance of Porphyromonas gingivalis ATCC 33277 to Direct Killing by Antimicrobial Peptides Is Protease Independent. Antimicrob. Agents Chemother. 52: 638-642 [Abstract] [Full Text]  
  • Ouhara, K., Komatsuzawa, H., Yamada, S., Shiba, H., Fujiwara, T., Ohara, M., Sayama, K., Hashimoto, K., Kurihara, H., Sugai, M. (2005). Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells. J Antimicrob Chemother 55: 888-896 [Abstract] [Full Text]  
  • de Repentigny, L., Lewandowski, D., Jolicoeur, P. (2004). Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection. Clin. Microbiol. Rev. 17: 729-759 [Abstract] [Full Text]  
  • Joly, S., Maze, C., McCray, P. B. Jr., Guthmiller, J. M. (2004). Human {beta}-Defensins 2 and 3 Demonstrate Strain-Selective Activity against Oral Microorganisms. J. Clin. Microbiol. 42: 1024-1029 [Abstract] [Full Text]  
  • Giacometti, A., Cirioni, O., Ghiselli, R., Mocchegiani, F., D'Amato, G., Circo, R., Orlando, F., Skerlavaj, B., Silvestri, C., Saba, V., Zanetti, M., Scalise, G. (2004). Cathelicidin Peptide Sheep Myeloid Antimicrobial Peptide-29 Prevents Endotoxin-induced Mortality in Rat Models of Septic Shock. Am. J. Respir. Crit. Care Med. 169: 187-194 [Abstract] [Full Text]  
  • Concannon, S. P., Crowe, T. D., Abercrombie, J. J., Molina, C. M., Hou, P., Sukumaran, D. K., Raj, P. A., Leung, K. -P. (2003). Susceptibility of oral bacteria to an antimicrobial decapeptide. J Med Microbiol 52: 1083-1093 [Abstract] [Full Text]  
  • Arzese, A., Skerlavaj, B., Tomasinsig, L., Gennaro, R., Zanetti, M. (2003). Antimicrobial activity of SMAP-29 against the Bacteroides fragilis group and clostridia. J Antimicrob Chemother 52: 375-381 [Abstract] [Full Text]  
  • Murakami, M., Ohtake, T., Dorschner, R.A., Gallo, R.L. (2002). Cathelicidin Antimicrobial Peptides are Expressed in Salivary Glands and Saliva. JDR 81: 845-850 [Abstract] [Full Text]  
  • Vargas, K. G., Joly, S. (2002). Carriage Frequency, Intensity of Carriage, and Strains of Oral Yeast Species Vary in the Progression to Oral Candidiasis in Human Immunodeficiency Virus-Positive Individuals. J. Clin. Microbiol. 40: 341-350 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»