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Antimicrobial Agents and Chemotherapy, November 2001, p. 3223-3225, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3223-3225.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Indication of Transposition of a Mobile DNA Element Containing the vat(D) and erm(B) Genes in Enterococcus faecium

Anette M. Hammerum,1,2,* Susan E. Flannagan,2 Don B. Clewell,2 and Lars Bogø Jensen1

Danish Veterinary Laboratory, Bülowsvej 27, DK-1790 Copenhagen V, Denmark,1 and Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 481092

Received 13 April 2001/Returned for modification 18 June 2001/Accepted 16 August 2001

The vat(D) and erm(B) genes encoding streptogramin resistance in Enterococcus faecium transferred together, and a direct physical link between erm(B) and vat(D) was detected. Both the vat(D) and erm(B) probes hybridized to fragments of different sizes in the donor and transconjugants, which indicated a transposition event.

* Corresponding author. Mailing address: Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark. Phone: (45) 32 68 33 99. Fax: (45) 32 68 38 87. E-mail: ama{at}ssi.dk.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3223-3225, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3223-3225.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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