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Antimicrobial Agents and Chemotherapy, November 2001, p. 3226-3228, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3226-3228.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antimicrobial Susceptibilities of 1,730 Haemophilus influenzae Respiratory Tract Isolates in Spain in 1998-1999

Francesc Marco,1 Juan García-de-Lomas,2 César García-Rey,3 Emilio Bouza,4 Lorenzo Aguilar,3,* Carlos Fernández-Mazarrasa,5 and The Spanish Surveillance Group for Respiratory Pathogensdagger

Microbiology Department, IDIBAPS, Hospital Cliníc, Barcelona1; Instituto Valenciano de Microbiología, Valencia2; Medical Department, GlaxoSmithKline, Tres Cantos, Madrid3; Microbiology Department, Hospital General Universitario Gregorio Marañón, Madrid4; and Microbiology Department, Residencia Marqués de Valdecilla, Santander,5 Spain

Received 28 December 2000/Returned for modification 25 June 2001/Accepted 8 August 2001

A beta -lactamase prevalence of 23% was found among 1,730 Haemophilus influenzae isolates. Ampicillin susceptibility was 70%, and 12% of beta -lactamase-negative strains presented diminished susceptibility to ampicillin (BLNAR phenotype). Susceptibility of 90% was found for cefaclor and clarithromycin, whereas it was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime. Ciprofloxacin-resistant (0.1%) and beta -lactamase-positive amoxicillin/clavulanate-resistant (BLPACR) phenotypes (0.1%) are anecdotal so far.

* Corresponding author. Mailing address: Medical Department, GlaxoSmithKline, C/Severo Ochoa, 2, 28760 Tres Cantos, Madrid, Spain. Phone: 34 91 807 5912. Fax: 34 91 807 0596. E-mail: lorenzo.aguilar-alfaro{at}gsk.com.

dagger Members of the Spanish Surveillance Group for Respiratory Pathogens are: E. Cercenado, Hospital Gregorio Marañón, Madrid; T. Jiménez de Anta, Hospital Clínic, Barcelona; A. García-Perea, S. García, and M. Güeni, Hospital La Paz, Madrid; E. Pérez-Trallero and J. Larruskain, Complejo Hospitalario Donostia, San Sebastián; J. Barrón and L. López, Hospital de Cruces, Baracaldo; C. Rubio and C. García, Hospital Clínico Universitario, Zaragoza; J. A. García-Rodríguez (Study Coordinator) and I. Trujillano, Hospital Clínico Universitario, Salamanca; J. Ruiz and E. Simarro, Hospital Virgen de la Arrixaca, Murcia; C. García-Riestra, B. Regueiro, A. Jato, and M. Prieto, Hospital Clínico Universitario, Santiago de Compostela; J. M. Nogueira, Hospital Dr. Peset, Valencia; C. Latorre and A. Gené, Hospital Sant Joan de Deu, Barcelona; M. de la Rosa, Hospital Virgen de las Nieves, Granada; E. Perea and L. Martínez, Hospital Virgen de la Macarena, Sevilla; A. M. Martín and F. Cañas, Hospital Insular, Las Palmas; M. Casal and A. Ibarra, Hospital Reina Sofía, Córdoba; D. Romero and M. González, Hospital Nuestra Señora de Alarcos, Ciudad Real; F. Baquero (Study Coordinator), Hospital Ramón y Cajal, Madrid; J. J. Granizo, Fundación Jiménez Díaz, Madrid; L. López and C. Gimeno, Instituto Valenciano de Microbiología, Valencia; and R. Dal-Ré, GlaxoSmithKline, Tres Cantos, Madrid, Spain.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3226-3228, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3226-3228.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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