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Antimicrobial Agents and Chemotherapy, November 2001, p. 3231-3233, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3231-3233.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Fungal Phospholipase Activity and Susceptibility to Lipid Preparations of Amphotericin B

Magnus Gottfredsson,1 Chad J. Jessup,2 Gary M. Cox,1,* John R. Perfect,1 and Mahmoud A. Ghannoum2

Departments of Medicine and Microbiology, Duke University Medical Center, Durham, North Carolina,1 and University Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio2

Received 25 January 2001/Returned for modification May 2001/Accepted 13 August 2001

It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.

* Corresponding author. Mailing address: Box 3281, Duke Medical Center, Durham, NC 27710. Phone: (919) 681-5055. Fax: (919) 684-8902. E-mail: gary.cox{at}duke.edu.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3231-3233, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3231-3233.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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