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Antimicrobial Agents and Chemotherapy, November 2001, p. 3262-3266, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3262-3266.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Eradication of Biofilm-Forming Staphylococcus epidermidis (RP62A) by a Combination of Sodium Salicylate and Vancomycin

Roy E. Polonio,1 Leonard A. Mermel,2 Gregory E. Paquette,3 and Jay F. Sperry1,*

Department of Biochemistry, Microbiology and Molecular Genetics,1 and Clinical Laboratory Science Program,3 University of Rhode Island, Kingston, Rhode Island 02881, and Division of Infectious Diseases, Brown University, and Rhode Island Hospital, Providence, Rhode Island 029032

Received 25 August 2000/Returned for modification 5 January 2001/Accepted 8 August 2001

Staphylococcus epidermidis is a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 µg of vancomycin per ml inhibited biofilm formation by S. epidermidis (RP62A) by >= 99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 µg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >99.9% reduction in viable count.

* Corresponding author. Mailing address: Department of Biochemistry, Microbiology and Molecular Genetics, University of Rhode Island, Kingston, RI 02881. Phone (401) 874-5900. Fax: (401) 874-2202. E-mail: jsp2116u{at}postoffice.uri.edu.

Antimicrobial Agents and Chemotherapy, November 2001, p. 3262-3266, Vol. 45, No. 11
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.11.3262-3266.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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