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Antimicrobial Agents and Chemotherapy, December 2001, p. 3601-3602, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3601-3602.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Hyperbaric Oxygen as an Adjunct in Zygomycosis: Randomized Controlled Trial in a Murine Model

Diana Marie Barratt,1,2,* Keith Van Meter,1,2 Philip Asmar,3 Terry Nolan,2 Chris Trahan,3 Lisardo Garcia-Covarrubias,4 and Stephen E. Metzinger3

Section of Emergency Medicine and Hyperbaric Medicine, Department of Medicine,1 and Department of Otolaryngology, Head and Neck Surgery,3 Louisiana State University, New Orleans, Louisiana 70112; Baromedical Research Institute, New Orleans, Louisiana 701142; and Department of Surgery, University of South Carolina, Columbia, South Carolina 292034

Received 21 August 2000/Returned for modification 24 February 2001/Accepted 30 August 2001

Zygomycosis was induced by injecting CD-1 mice with 5 mg of intraperitoneal deferoxamine and then 106 CFU of intravenous and intrasinus Rhizopus arrhizus. The addition of hyperbaric oxygen (2.0 atm absolute twice daily) to amphotericin B did not improve survival over that achieved with amphotericin B and placebo air treatments.

* Corresponding author. Present address: Department of Neurology, Louisiana State University, 1542 Tulane Ave., New Orleans, LA 70112. Phone: (504) 568-4081. Fax: (504) 568-7130. E-mail: dbarratt{at}bellsouth.net.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3601-3602, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3601-3602.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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