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Antimicrobial Agents and Chemotherapy, December 2001, p. 3607-3609, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3607-3609.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Pharmacokinetic-Pharmacodynamic Modeling of Electroencephalogram Effect of Imipenem in Rats with Acute Renal Failure

Antoine Dupuis,1,2 Anne Limosin,1,2 Joël Paquereau,3 Olivier Mimoz,4 William Couet,1,* and Serge Bouquet1,2

Laboratoire de Biopharmacie1 and Laboratoire de Physiologie3 Faculté de Médecine & Pharmacie, 86005 Poitiers Cedex, Laboratoire de Pharmacocinétique, CHU la Milétrie, 86021 Poitiers Cedex,2 and Département d'Anesthésie et de Réanimation Chirurgicale, CHU la Milétrie, 86021 Poitiers Cedex,4 France

Received 12 March 2001/Accepted 30 August 2001

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estimate the dose of imipenem required to induce an observable but nonlethal EEG effect on the assumption that only the pharmacokinetic parameters of the model would be affected by renal failure. Good agreement was observed between the predicted and observed effects.

* Corresponding author. Mailing address: Laboratoire de Biopharmacie, Faculté de Médecine & Pharmacie, 34 rue du Jardin des Plantes, B.P. 199, 86005 Poitiers Cedex, France. Phone: 33 5 49 45 43 79. Fax: 33 5 49 45 43 78. E-mail: william.couet{at}univ-poitiers.fr.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3607-3609, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3607-3609.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Marchand, S., Dahyot, C., Lamarche, I., Plan, E., Mimoz, O., Couet, W. (2005). Lack of Effect of Experimental Hypovolemia on Imipenem Muscle Distribution in Rats Assessed by Microdialysis. Antimicrob. Agents Chemother. 49: 4974-4979 [Abstract] [Full Text]  
  • Marchand, S., Dahyot, C., Lamarche, I., Mimoz, O., Couet, W. (2005). Microdialysis Study of Imipenem Distribution in Skeletal Muscle and Lung Extracellular Fluids of Noninfected Rats. Antimicrob. Agents Chemother. 49: 2356-2361 [Abstract] [Full Text]  
  • Limosin, A., Dupuis, A., Lamarche, I., Mimoz, O., Paquereau, J., Couet, W. (2004). Pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of imipenem in rats with experimental hypovolaemia or endotoxaemia. J Antimicrob Chemother 54: 187-192 [Abstract] [Full Text]  


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