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Antimicrobial Agents and Chemotherapy, December 2001, p. 3610-3612, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3610-3612.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Chloramphenicol-Sensitive Escherichia coli Strain Expressing the Chloramphenicol Acetyltransferase (cat) Gene

Joanna Potrykus1 and Grzegorz Wegrzyn1,2,*

Department of Molecular Biology, University of Gdañsk, 80-822 Gdañsk,1 and Marine Biology Center, Polish Academy of Sciences, 81-347 Gdynia,2 Poland

Received 18 April 2001/Returned for modification 16 July 2001/Accepted 30 August 2001

An Escherichia coli strain (strain CM2555) bearing the chloramphenicol acetyltransferase (cat) gene was found to be sensitive to chloramphenicol. We demonstrate that the cat gene is efficiently expressed in strain CM2555. Our results suggest that decreased levels of acetyl coenzyme A in cat-expressing CM2555 cells in the presence of chloramphenicol may cause the bacterium to be sensitive to this antibiotic.

* Corresponding author. Mailing address: Department of Molecular Biology, University of Gdañsk, Kładki 24, 80-822 Gdañsk, Poland. Phone: 48 (58) 346 3014. Fax: 48 (58) 301 0072. E-mail: wegrzyn{at}biotech.univ.gda.pl.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3610-3612, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3610-3612.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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