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Antimicrobial Agents and Chemotherapy, December 2001, p. 3613-3615, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3613-3615.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Postantibiotic Effects of ABT-773 and Amoxicillin-Clavulanate against Streptococcus pneumoniae and Haemophilus influenzae

Melinda M. Neuhauser,1 Jennifer L. Prause,2 Larry H. Danziger,2 and Susan L. Pendland2,*

The University of Houston College of Pharmacy, Department of Clinical Sciences and Administration, Houston, Texas,1 and The University of Illinois at Chicago, Department of Pharmacy Practice, Microbiology Research Laboratory, Chicago, Illinois2

Received 22 January 2001/Returned for modification 23 July 2001/Accepted 4 September 2001

This study determined the postantibiotic effect (PAE) of ABT-773 versus that of amoxicillin-clavulanate against clinical isolates of Streptococcus pneumoniae and Haemophilus influenzae. The PAEs of ABT-773 and amoxicillin-clavulanate ranged from 2.3 to 6.0 h and 0 to 2.2 h against S. pneumoniae and from 2.7 to 9.1 h and 0 to 0.8 h against H. influenzae, respectively.

* Corresponding author. Mailing address: The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice (M/C 886), 833 South Wood St., Chicago, IL 60612. Phone: (312) 996-8639. Fax: (312) 413-1797. E-mail: pendland{at}uic.edu.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3613-3615, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3613-3615.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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