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Antimicrobial Agents and Chemotherapy, December 2001, p. 3629-3630, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3629-3630.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activity of PNU-100766 (Linezolid), a New Oxazolidinone Antimicrobial, against Nocardia brasiliensis

Lucio Vera-Cabrera, Alejandra Gómez-Flores, Wendy G. Escalante-Fuentes, and Oliverio Welsh*

Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatologia, Hospital Universitario, Monterrey, N.L., México

Received 6 November 2000/Returned for modification 3 June 2001/Accepted 14 September 2001

The in vitro activity of a novel oxazolidinone, linezolid, was studied by comparing the activity of linezolid with those of amikacin, trimethoprim-sulfamethoxazole, and amoxicillin-clavulanic acid against 25 strains of Nocardia brasiliensis isolated from patients with mycetoma. All N. brasiliensis strains tested were sensitive to linezolid (MIC at which 90% of strains are inhibited [MIC90], 2 µg/ml; MIC50, 1 µg/ml). This antimicrobial might constitute a good alternative for treatment of actinomycetoma.

* Corresponding author. Mailing address: Servicio de Dermatologia, Hospital Universitario, Madero y Gonzalitos, Colonia Mitras Centro, C.P. 64460, Monterrey, N.L., México. Phone: (528) 348 03 83. Fax: (528) 348 44 07. E-mail: owelsh{at}yahoo.com.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3629-3630, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3629-3630.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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