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Antimicrobial Agents and Chemotherapy, December 2001, p. 3631-3634, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3631-3634.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Postantibiotic Effects of Antituberculosis Agents Alone and in Combination

Chiu-Yeung Chan,1,* Carrie Au-Yeang,1 Wing-Wai Yew,2 Mamie Hui,1 and Augustine F. B. Cheng1

Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories,1 and Tuberculosis & Chest Unit, Grantham Hospital, Aberdeen,2 Hong Kong

Received 18 December 2000/Returned for modification 1 June 2001/Accepted 16 September 2001

The postantibiotic effects (PAEs) of seven antimycobacterial agents, tested at their respective peak concentrations in serum alone and in different combinations, against Mycobacterium tuberculosis ATCC 27294 were studied with a radiometric culture system in parallel with the viable count method. Rifampin gave the longest PAE (67.8 h) among the drugs used alone, and combinations of first-line drugs generally gave PAEs longer than 120 h. The data obtained might help provide a better understanding of the scientific basis of intermittently administered antituberculosis chemotherapy.

* Corresponding author. Mailing address: Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. Phone: (852)-2632-2875. Fax: (852)-2647-3227. E-mail: chiuychan{at}cuhk.edu.hk.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3631-3634, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3631-3634.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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