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Antimicrobial Agents and Chemotherapy, December 2001, p. 3635-3639, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3635-3639.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multidrug Resistant Mycobacterium leprae from Patients with Leprosy

Shinji Maeda,1,2 Masanori Matsuoka,1,* Noboru Nakata,1 Masanori Kai,1 Yumi Maeda,1 Ken Hashimoto,1 Hiroaki Kimura,1 Kazuo Kobayashi,2 and Yoshiko Kashiwabara1

Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002,1 and Department of Host Defense, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585,2 Japan

Received 4 May 2001/Returned for modification 8 August 2001/Accepted 17 September 2001

Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.

* Corresponding author. Mailing address: Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan. Phone: 81-42-391-8211. Fax: 81-42-394-9092. E-mail: matsuoka{at}nih.go.jp.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3635-3639, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3635-3639.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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