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Antimicrobial Agents and Chemotherapy, December 2001, p. 3635-3639, Vol. 45, No. 12
Leprosy Research Center, National Institute
of Infectious Diseases, Higashimurayama-shi, Tokyo
189-0002,1 and Department of Host
Defense, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585,2 Japan
Received 4 May 2001/Returned for modification 8 August
2001/Accepted 17 September 2001
Sequences of the folP1, rpoB,
and gyrA genes were analyzed for 88 isolates of
Mycobacterium leprae from leprosy patients in Japan,
Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates
(14.8%) showed representative mutations in more than two genes,
suggesting the emergence of multidrug-resistant M. leprae.
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.12.3635-3639.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Multidrug Resistant Mycobacterium
leprae from Patients with Leprosy
*
Corresponding author. Mailing address: Leprosy Research
Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan. Phone: 81-42-391-8211. Fax:
81-42-394-9092. E-mail: matsuoka{at}nih.go.jp.
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