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Antimicrobial Agents and Chemotherapy, December 2001, p. 3660-3662, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3660-3662.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mechanism of Action of the Des-F(6) Quinolone BMS-284756 Measured by Supercoiling Inhibition and Cleavable Complex Assays

Ping Wu, Laura E. Lawrence, Kenneth L. Denbleyker, and John F. Barrett*

Bristol-Myers Squibb Company Pharmaceutical Research Institute, Wallingford, Connecticut

Received 20 April 2001/Returned for modification 20 August 2001/Accepted 12 September 2001

BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the supercoiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has the same mechanism of action against DNA gyrase as other quinolones and a similar level of potency.

* Corresponding author. Present address: Merck Research Laboratories, Merck & Co., Inc., RY80Y-315, 126 E. Lincoln Ave., Rahway, NJ 07065-0900. Phone: (732) 594-3509. Fax: (732) 594-5878. E-mail: John_Barrett2{at}merck.com.

Antimicrobial Agents and Chemotherapy, December 2001, p. 3660-3662, Vol. 45, No. 12
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.12.3660-3662.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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