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Antimicrobial Agents and Chemotherapy, February 2001, p. 593-595, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.593-595.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Emergence of Multiple Human Cytomegalovirus Ganciclovir-Resistant Mutants with Deletions and Substitutions within the UL97 Gene in a Patient with Severe Combined Immunodeficiency

Dana G. Wolf,^* Isaac Yaniv, Shai Ashkenazi, and Alik Honigman

Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, Jerusalem, and Schneider Children Medical Center, Petach Tiqva, Israel

Received 10 April 2000/Returned for modification 7 August 2000/Accepted 7 November 2000

Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.

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^* Corresponding author. Mailing address: Dept. of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, P.O.B. 12000, Jerusalem, 91120, Israel. Phone: 972-2-6776-543. Fax: 972-2-6434-434. E-mail: wolfd{at}md2.huji.ac.il.

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Antimicrobial Agents and Chemotherapy, February 2001, p. 593-595, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.593-595.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

This article has been cited by other articles:

• Lurain, N. S., Weinberg, A., Crumpacker, C. S., Chou, S. (2001). Sequencing of Cytomegalovirus UL97 Gene for Genotypic Antiviral Resistance Testing. Antimicrob. Agents Chemother. 45: 2775-2780 [Abstract] [Full Text]