This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clemons, K. V.
Right arrow Articles by Stevens, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clemons, K. V.
Right arrow Articles by Stevens, D. A.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 2001, p. 612-615, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.612-615.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits

Karl V. Clemons,1,2,3,* Raymond A. Sobel,4,5 Paul L. Williams,1,6 and David A. Stevens1,2,3

California Institute for Medical Research,1 and Department of Medicine, Division of Infectious Diseases,2 Santa Clara Valley Medical Center, San Jose, California 95128; Department of Medicine, Division of Infectious Diseases and Geographic Medicine,3 and Department of Pathology,4 Stanford University, Stanford, California 94305; Palo Alto Veterans Affairs Health Care System,5 Palo Alto, California 94304; and Kaweah Delta District Hospital, Visalia, CA 932916

Received 18 January 2000/Returned for modification 28 July 2000/Accepted 25 October 2000

The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits than did ABCD. Clinically and histologically, ABCD was about threefold less toxic than AMB after a single dose and 3- to 30-fold less toxic after multiple dosing. These data are encouraging for the potential use of ABCD as an intrathecal treatment.

* Corresponding author. Mailing address: Division of Infectious Diseases, Santa Clara Valley Medical Center, 751 South Bascom Ave., San Jose, CA 95128. Phone: (408) 998-4557. Fax: (408) 998-2723. E-mail: Karl.Clemons{at}slip.net.

Antimicrobial Agents and Chemotherapy, February 2001, p. 612-615, Vol. 45, No. 2
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.2.612-615.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Calbo, E., Romani, V., Xercavins, M., Gomez, L., Vidal, C. G., Quintana, S., Vila, J., Garau, J. (2006). Risk factors for community-onset urinary tract infections due to Escherichia coli harbouring extended-spectrum {beta}-lactamases. J Antimicrob Chemother 57: 780-783 [Abstract] [Full Text]  
  • Clemons, K. V., Stevens, D. A. (2004). Comparative Efficacies of Four Amphotericin B Formulations--Fungizone, Amphotec (Amphocil), AmBisome, and Abelcet--against Systemic Murine Aspergillosis. Antimicrob. Agents Chemother. 48: 1047-1050 [Abstract] [Full Text]  
  • Cannon, J. P., Fiscella, R., Pattharachayakul, S., Garey, K. W., De Alba, F., Piscitelli, S., Edward, D. P., Danziger, L. H. (2003). Comparative Toxicity and Concentrations of Intravitreal Amphotericin B Formulations in a Rabbit Model. IOVS 44: 2112-2117 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»