This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horowitz, H. W.
Right arrow Articles by Wu, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horowitz, H. W.
Right arrow Articles by Wu, J. M.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 2001, p. 786-788, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.786-788.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Antimicrobial Susceptibility of Ehrlichia phagocytophila

Harold W. Horowitz,1,* T.-C. Hsieh,2 Maria E. Aguero-Rosenfeld,3 Fatemeh Kalantarpour,1 Ishraq Chowdhury,1 Gary P. Wormser,1 and Joseph M. Wu2

Division of Infectious Diseases and Departments of Medicine,1 Biochemistry and Molecular Biology,2 and Pathology,3 New York Medical College, Valhalla, New York 10595

Received 31 July 2000/Returned for modification 28 September 2000/Accepted 20 December 2000

Human granulocytic ehrlichiosis is a recently described disease caused by an obligate intracellular gram-negative organism recently named Ehrlichia phagocytophila. To expand our knowledge of the susceptibility of E. phagocytophila, we tested six New York State isolates for susceptibility to 12 antimicrobials using an HL-60 cell culture system. All of the isolates were susceptible to doxycycline (MIC, <= 0.125 µg/ml; minimum bactericidal concentration [MBC], 0.125 to 0.5 µg/ml), rifampin (MIC, <= 0.125 µg/ml; MBC, <= 0.125 µg/ml), ofloxacin (MIC, <= 2 µg/ml; MBC, <= 2 µg/ml), levofloxacin (MIC, <= 1 µg/ml; MBC, <= 1 µg/ml), and trovafloxacin (MIC, <= 0.032 µg/ml; MBC, <= 0.032 µg/ml). Isolates were uniformly resistant to amoxicillin, ceftriaxone, erythromycin, azithromycin, clarithromycin, and amikacin. For one strain, the MBC of chloramphenicol was <= 8 µg/ml. These data suggest that quinolone antibiotics and rifampin may be alternative agents for patients with intolerance to tetracyclines.

* Corresponding author. Mailing address: Westchester Medical Center, Division of Infectious Diseases, Room 209, Macy Pavilion, Valhalla, NY 10595. Phone: (914) 493-8865. Fax: (914) 493-7289. E-mail: Harold_Horowitz{at}nymc.edu.

Antimicrobial Agents and Chemotherapy, March 2001, p. 786-788, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.786-788.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Zeidner, N. S., Massung, R. F., Dolan, M. C., Dadey, E., Gabitzsch, E., Dietrich, G., Levin, M. L. (2008). A sustained-release formulation of doxycycline hyclate (Atridox) prevents simultaneous infection of Anaplasma phagocytophilum and Borrelia burgdorferi transmitted by tick bite. J Med Microbiol 57: 463-468 [Abstract] [Full Text]  
  • Barbet, A. F., Lundgren, A. M., Alleman, A. R., Stuen, S., Bjoersdorff, A., Brown, R. N., Drazenovich, N. L., Foley, J. E. (2006). Structure of the Expression Site Reveals Global Diversity in MSP2 (P44) Variants in Anaplasma phagocytophilum. Infect. Immun. 74: 6429-6437 [Abstract] [Full Text]  
  • Swanson, S. J., Neitzel, D., Reed, K. D., Belongia, E. A. (2006). Coinfections Acquired from Ixodes Ticks. Clin. Microbiol. Rev. 19: 708-727 [Abstract] [Full Text]  
  • Branger, S., Rolain, J. M., Raoult, D. (2004). Evaluation of Antibiotic Susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by Real-Time PCR. Antimicrob. Agents Chemother. 48: 4822-4828 [Abstract] [Full Text]  
  • Fenollar, F., Maurin, M., Raoult, D. (2003). Wolbachia pipientis Growth Kinetics and Susceptibilities to 13 Antibiotics Determined by Immunofluorescence Staining and Real-Time PCR. Antimicrob. Agents Chemother. 47: 1665-1671 [Abstract] [Full Text]  
  • Barbet, A. F., Meeus, P. F. M., Belanger, M., Bowie, M. V., Yi, J., Lundgren, A. M., Alleman, A. R., Wong, S. J., Chu, F. K., Munderloh, U. G., Jauron, S. D. (2003). Expression of Multiple Outer Membrane Protein Sequence Variants from a Single Genomic Locus of Anaplasma phagocytophilum. Infect. Immun. 71: 1706-1718 [Abstract] [Full Text]  
  • Maurin, M., Bakken, J. S., Dumler, J. S. (2003). Antibiotic Susceptibilities of Anaplasma (Ehrlichia) phagocytophilum Strains from Various Geographic Areas in the United States. Antimicrob. Agents Chemother. 47: 413-415 [Abstract] [Full Text]  
  • Maurin, M., Abergel, C., Raoult, D. (2001). DNA Gyrase-Mediated Natural Resistance to Fluoroquinolones in Ehrlichia spp.. Antimicrob. Agents Chemother. 45: 2098-2105 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»