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Antimicrobial Agents and Chemotherapy, March 2001, p. 789-793, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.789-793.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of the Novel Ketolide Telithromycin (HMR 3647) against Erythromycin-Resistant Streptococcus Species

Jari Jalava,1,* Janne Kataja,1 Helena Seppälä,1,2 and Pentti Huovinen1

Antimicrobial Research Laboratory, National Public Health Institute, Turku,1 and Department of Ophthalmology, University of Turku,2 20520 Turku, Finland

Received 14 August 2000/Returned for modification 16 November 2000/Accepted 13 December 2000

The in vitro susceptibilities of 184 erythromycin-resistant streptococci to a novel ketolide, telithromycin (HMR 3647), were tested. These clinical isolates included 111 Streptococcus pyogenes, 18 group C streptococcus, 18 group G streptococcus, and 37 Streptococcus pneumoniae strains. The MICs for all but eight S. pyogenes strains were <= 0.5 µg/ml, indicating that telithromycin is active in vitro against erythromycin-resistant Streptococcus strains. All strains for which MICs were >= 1 µg/ml had an erm(B) resistance gene and six strains for which MICs were >= 4 µg/ml had a constitutive erm(B) gene (MIC range, 4 to 64 µg/ml). Interestingly, for S. pneumoniae strains with a constitutive erm(B) gene, MICs were <= 0.25 µg/ml (MIC range, <= 0.008 to 0.25 µg/ml). Our in vitro data show that for S. pyogenes strains which constitutively express the erm(B) methylase gene, MICs are so high that the strains might be clinically resistant to telithromycin.

* Corresponding author. Mailing address: National Public Health Institute, Turku, Kiinamyllynkatu 13, 20520 Turku, Finland. Phone: 358-2-2519255. Fax: 358-2-2519254. E-mail: jari.jalava{at}utu.fi.

Antimicrobial Agents and Chemotherapy, March 2001, p. 789-793, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.789-793.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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