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Antimicrobial Agents and Chemotherapy, March 2001, p. 932-935, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.932-935.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Controlled Trial of 3-Day Quinine-Clindamycin Treatment versus 7-Day Quinine Treatment for Adult Travelers with Uncomplicated Falciparum Malaria Imported from the Tropics

Phillippe Parola,1 Stephane Ranque,1 Sekene Badiaga,1 Mohamadou Niang,1 Olivier Blin,2 Jean-Jacques Charbit,3 Jean Delmont,1 and Philippe Brouqui1,*

Service des Maladies Tropicales et Infectieuses1 and Pharmacie Centrale,3 CHU Nord, 13015 Marseille, and CPCET, CHU Timone, 13005 Marseille,2 France

Received 13 September 2000/Returned for modification 17 October 2000/Accepted 15 November 2000

We conducted a randomized, double-blind, placebo-controlled trial to compare a 3-day quinine-clindamycin regimen (group QC) with a 7-day quinine regimen (group Q) for the treatment of uncomplicated Plasmodium falciparum malaria in travelers returning from the tropics. A total of 55 and 53 patients in groups Q and QC were analyzed, respectively. Adverse effects were similar in both groups, although two patients in group Q had severe adverse reactions, leading to the cessation of treatment. The 28-day cure rate for the evaluated patients (per-protocol analysis) was 100% for group QC, whereas it was 96.3% for group Q (P = 0.5). The 28-day cure rate in the intention-to-treat analysis was 96.2% for group QC, whereas it was 94.6% for group Q (P = 1). There were no significant differences between the two regimens with regard to parasite and fever clearance times. Our study shows that the 3-day quinine-clindamycin regimen is well tolerated and compares favorably with a 7-day quinine treatment. This short-term regimen had previously been evaluated only in areas of endemicity. According to our results, the 3-day quinine-clindamycin regimen may be an alternative for the treatment of imported uncomplicated P. falciparum malaria in travelers returning from the tropics.

* Corresponding author. Mailing address: Service des Maladies Tropicales et Infectieuses, CHU Nord, 13015 Marseille, France. Phone: (33) 4 91 96 89 36. Fax: (33) 4 91 96 89 38. E-mail: Philippe.Brouqui{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, March 2001, p. 932-935, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.932-935.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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