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Antimicrobial Agents and Chemotherapy, March 2001, p. 936-937, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.936-937.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Efficacy of an Evernimicin (SCH27899) In Vitro and in an Animal Model of Lyme Disease

Charles S. Pavia,1,2,* Gary P. Wormser,2 John Nowakowski,2 and Anthony Cacciapuoti3

NYCOM Microbiology and Immunodiagnostic Laboratory of the New York Institute of Technology, Old Westbury, New York 11568;1 Division of Infectious Diseases, Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, New York 105952; and Schering-Plough Research Institute, Kenilworth, New Jersey 070733

Received 2 June 2000/Returned for modification 3 October 2000/Accepted 21 November 2000

The MICs of evernimicin at which 90% of Borrelia burgdorferi patient isolates were inhibited ranged from 0.1 to 0.5 µg/ml. Evernimicin was as effective as ceftriaxone against B. burgdorferi in a murine model of experimental Lyme disease. As assessed by culturing the urinary bladders of infected C3H mice, no live Borrelia isolates were recoverable following antibiotic treatment.

* Corresponding author. Mailing address: NYCOM Microbiology Laboratory, Old Westbury, NY 11568. Phone: (516) 686-3778. Fax: (516) 686-3832. E-mail: cpavia{at}iris.nyit.edu.

Antimicrobial Agents and Chemotherapy, March 2001, p. 936-937, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.936-937.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.