In Vitro Development of Resistance to Six Quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus

doi:10.1128/AAC.45.3.938-942.2001

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Antimicrobial Agents and Chemotherapy, March 2001, p. 938-942, Vol. 45, No. 3
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.3.938-942.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Development of Resistance to Six Quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus

Mechthild Boos,¹ Susanne Mayer,¹ Ansgar Fischer,¹ Karl Köhrer,¹ Sibylle Scheuring,¹ Peter Heisig,² Jan Verhoef,³ Ad C. Fluit,³ and F.-J. Schmitz¹^,³^,^*

Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf,¹ and Institute of Pharmaceutical Microbiology, University of Bonn, Bonn,² Germany, and Eijkman-Winkler Institute for Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands³

Received 24 July 2000/Returned for modification 11 September 2000/Accepted 27 November 2000

Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs ofciprofloxacin, sparfloxacin, gatifloxacin, moxifloxacin, clinafloxacin,and gemifloxacin during a 10-day period. Subculturing led to resistancedevelopment, regardless of the initial potencies of the quinolones.None of the quinolones was associated with a significantly slowerrate of resistancedevelopment.

^* Corresponding author. Mailing address: Institute for Medical Microbiology and Virology, Heinrich-Heine-Universität Düsseldorf,Universitätsstraße 1, Geb. 22.21, 40225 Düsseldorf, Germany.Phone and fax: 0049-2132-72040. E-mail: schmitfj{at}uni-duesseldorf.de.

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