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Antimicrobial Agents and Chemotherapy, March 2001, p. 986-989, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.986-989.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Molecular Analysis of Tn1546-Like Elements in Vancomycin-Resistant Enterococci Isolated from Patients in Europe Shows Geographic Transposon Type Clustering

Marinus A. Schouten,*,1 Rob J. L. Willems,2 Wilma A. G. Kraak,1 Janetta Top,2 Jacomina A. A. Hoogkamp-Korstanje,1 and Andreas Voss1

Department of Medical Microbiology, University Hospital St. Radboud, 6500 HB Nijmegen,1 and Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, 3720 BA Bilthoven,2 The Netherlands

Received 19 June 2000/Returned for modification 28 September 2000/Accepted 15 December 2000

Resistance mechanism relatedness was studied in 18 clinical, European vanA vancomycin-resistant enterococci. Molecular analysis revealed 10 Tn1546-like elements, suggesting two evolutionary lineages. Lineage I dominated the European mainland, and lineage II dominated the United Kingdom and Israel. Geographic clustering reflected different types of meat consumption between countries, since each lineage is associated with colonization of different animals.

* Corresponding author. Mailing address: Department of Medical Microbiology, Rijnstate Hospital, Wagnerlaan 55, 6815 AD Arnhem, The Netherlands. Phone: 00 24 378 7276. Fax: 00 24 378 7279. E-mail: rschouten{at}rijnstate.nl.

Antimicrobial Agents and Chemotherapy, March 2001, p. 986-989, Vol. 45, No. 3
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.3.986-989.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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