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Antimicrobial Agents and Chemotherapy, April 2001, p. 1281-1283, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1281-1283.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro and in Vivo Combinations of Cefotaxime and Minocycline against Aeromonas hydrophila

Wen-Chien Ko,1,2 Hsin-Chun Lee,1 Yin-Ching Chuang,1,2,dagger Shih-Hua Ten,3 Chia-Yang Su,4 and Jiunn-Jong Wu4,*

Department of Internal Medicine, National Cheng Kung University Hospital,1 and Departments of Medicine,2 Microbiology and Immunology,3 and Medical Technology,4 National Cheng Kung University Medical College, Tainan, Taiwan

Received 18 August 2000/Returned for modification 1 November 2000/Accepted 5 January 2001

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

* Corresponding author. Mailing address: Department of Medical Technology, National Cheng Kung University Medical College, No. 1 University Rd., Tainan, Taiwan. Phone: 886-6-2353535, ext. 5775. Fax: 886-6-2363956. E-mail: jjwu{at}mail.ncku.edu.tw.

dagger Present address: Department of Medical Research, Chi Mei Medical Center, Yung Kang City, Tainan 710, Taiwan.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1281-1283, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1281-1283.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Ko, W.-C., Chiang, S.-R., Lee, H.-C., Tang, H.-J., Wang, Y.-Y., Chuang, Y.-C. (2003). In Vitro and In Vivo Activities of Fluoroquinolones against Aeromonas hydrophila. Antimicrob. Agents Chemother. 47: 2217-2222 [Abstract] [Full Text]  


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