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Antimicrobial Agents and Chemotherapy, April 2001, p. 1295-1297, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1295-1297.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vitro Activities of Linezolid against Multiple Nocardia Species

Barbara A. Brown-Elliott,1,* Shelby C. Ward,2 Christopher J. Crist,1 Linda B. Mann,1 Rebecca W. Wilson,1 and Richard J. Wallace Jr.1

Department of Microbiology, University of Texas Health Center, Tyler,1 and Microbiology Specialists, Inc., Houston,2 Texas

Received 15 May 2000/Returned for modification 29 December 2000/Accepted 18 January 2001

Linezolid was tested by broth microdilution against 140 clinical Nocardia isolates belonging to seven species. The MIC at which 50% of the strains are inhibited (MIC50) and MIC90 for all species other than Nocardia farcinica were 2 and 4 µg/ml. Linezolid is the first antimicrobial agent demonstrated to be active against all Nocardia species.

* Corresponding author. Mailing address: Department of Microbiology, The University of Texas Health Center, 11937 U.S. Hwy. 271, Tyler, TX 75708. Phone: (903) 877-7685. Fax: (903) 877-7652. E-mail: barbara.elliott{at}uthct.edu.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1295-1297, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1295-1297.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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