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Antimicrobial Agents and Chemotherapy, April 2001, p. 1295-1297, Vol. 45, No. 4
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.4.1295-1297.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
In Vitro Activities of Linezolid against Multiple
Nocardia Species
Barbara A.
Brown-Elliott,1,*
Shelby C.
Ward,2
Christopher J.
Crist,1
Linda B.
Mann,1
Rebecca W.
Wilson,1 and
Richard J.
Wallace Jr.1
Department of Microbiology, University of
Texas Health Center, Tyler,1 and
Microbiology Specialists, Inc.,
Houston,2 Texas
Received 15 May 2000/Returned for modification 29 December
2000/Accepted 18 January 2001
Linezolid was tested by broth microdilution against 140 clinical
Nocardia isolates belonging to seven species. The MIC at which 50% of the strains are inhibited (MIC50) and
MIC90 for all species other than Nocardia
farcinica were 2 and 4 µg/ml. Linezolid is the first
antimicrobial agent demonstrated to be active against all
Nocardia species.
*
Corresponding author. Mailing address: Department of
Microbiology, The University of Texas Health Center, 11937 U.S. Hwy. 271, Tyler, TX 75708. Phone: (903) 877-7685. Fax: (903) 877-7652. E-mail: barbara.elliott{at}uthct.edu.
Antimicrobial Agents and Chemotherapy, April 2001, p. 1295-1297, Vol. 45, No. 4
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.4.1295-1297.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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