This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guerra, B.
Right arrow Articles by Mendoza, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guerra, B.
Right arrow Articles by Mendoza, M. C.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2001, p. 1305-1308, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1305-1308.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multidrug Resistance Is Mediated by Large Plasmids Carrying a Class 1 Integron in the Emergent Salmonella enterica Serotype [4,5,12:i:-]

Beatriz Guerra, Sara M. Soto, Jose M. Argüelles, and M. Carmen Mendoza*

Área de Microbiología, Departamento de Biología Funcional, Universidad de Oviedo, 33006 Oviedo, Principado de Asturias, Spain

Received 7 August 2000/Returned for modification 24 October 2000/Accepted 10 January 2001

A multidrug-resistant Salmonella enterica serotype [4,5,12:i:-] clone carried a class 1 integron harboring dfrA12 and aadA2 gene cassettes and blaTEM-1, aac(3)-IV, cmlA1, and tetA genes located in large plasmids of about 140 kb (carrying spv) or 120 kb (lacking spv). Several segregants, lacking multidrug resistance, contained a plasmid smaller than the parental one and no longer hybridized with probes for the lost resistances. The genes mediating resistance to ampicillin, chloramphenicol, and tetracycline in the [4,5,12:i:-] clone are different from those found in the pentadrug-resistant serotype Typhimurium DT104 clone.

* Corresponding author. Mailing address: Área de Microbiología. Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Calle Julián Clavería 6, 33006 Oviedo, Spain. Phone: 34-985-103560. Fax: 34-985-103148. E-mail: camf{at}sauron.quimica.uniovi.es.

Antimicrobial Agents and Chemotherapy, April 2001, p. 1305-1308, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1305-1308.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nogrady, N., Toth, A., Kostyak, A., Paszti, J., Nagy, B. (2007). Emergence of multidrug-resistant clones of Salmonella Infantis in broiler chickens and humans in Hungary. J Antimicrob Chemother 60: 645-648 [Abstract] [Full Text]  
  • Herrero, A., Rodicio, M. R., Gonzalez-Hevia, M. A., Mendoza, M. C. (2006). Molecular epidemiology of emergent multidrug-resistant Salmonella enterica serotype Typhimurium strains carrying the virulence resistance plasmid pUO-StVR2. J Antimicrob Chemother 57: 39-45 [Abstract] [Full Text]  
  • Agerso, Y., Sandvang, D. (2005). Class 1 Integrons and Tetracycline Resistance Genes in Alcaligenes, Arthrobacter, and Pseudomonas spp. Isolated from Pigsties and Manured Soil. Appl. Environ. Microbiol. 71: 7941-7947 [Abstract] [Full Text]  
  • Hegde, N. V., Cook, M. L., Wolfgang, D. R., Love, B. C., Maddox, C. C., Jayarao, B. M. (2005). Dissemination of Salmonella enterica subsp. enterica Serovar Typhimurium var. Copenhagen Clonal Types through a Contract Heifer-Raising Operation. J. Clin. Microbiol. 43: 4208-4211 [Abstract] [Full Text]  
  • Poole, K. (2005). Efflux-mediated antimicrobial resistance. J Antimicrob Chemother 56: 20-51 [Abstract] [Full Text]  
  • Villa, L., Carattoli, A. (2005). Integrons and Transposons on the Salmonella enterica Serovar Typhimurium Virulence Plasmid. Antimicrob. Agents Chemother. 49: 1194-1197 [Abstract] [Full Text]  
  • Chiu, C.-H., Su, L.-H., Chu, C. (2004). Salmonella enterica Serotype Choleraesuis: Epidemiology, Pathogenesis, Clinical Disease, and Treatment. Clin. Microbiol. Rev. 17: 311-322 [Abstract] [Full Text]  
  • Chen, S., Zhao, S., White, D. G., Schroeder, C. M., Lu, R., Yang, H., McDermott, P. F., Ayers, S., Meng, J. (2004). Characterization of Multiple-Antimicrobial-Resistant Salmonella Serovars Isolated from Retail Meats. Appl. Environ. Microbiol. 70: 1-7 [Abstract] [Full Text]  
  • Miko, A., Pries, K., Schroeter, A., Helmuth, R. (2003). Multiple-Drug Resistance in D-Tartrate-Positive Salmonella enterica Serovar Paratyphi B Isolates from Poultry Is Mediated by Class 2 Integrons Inserted into the Bacterial Chromosome. Antimicrob. Agents Chemother. 47: 3640-3643 [Abstract] [Full Text]  
  • Faldynova, M., Pravcova, M., Sisak, F., Havlickova, H., Kolackova, I., Cizek, A., Karpiskova, R., Rychlik, I. (2003). Evolution of Antibiotic Resistance in Salmonella enterica Serovar Typhimurium Strains Isolated in the Czech Republic between 1984 and 2002. Antimicrob. Agents Chemother. 47: 2002-2005 [Abstract] [Full Text]  
  • de la Torre, E., Zapata, D., Tello, M., Mejia, W., Frias, N., Garcia Pena, F. J., Mateu, E. M., Torre, E. (2003). Several Salmonella enterica subsp. enterica Serotype 4,5,12:i:- Phage Types Isolated from Swine Samples Originate from Serotype Typhimurium DT U302. J. Clin. Microbiol. 41: 2395-2400 [Abstract] [Full Text]  
  • Soto, S. M., Gonzalez-Hevia, M. A., Mendoza, M. C. (2003). Antimicrobial resistance in clinical isolates of Salmonella enterica serotype Enteritidis: relationships between mutations conferring quinolone resistance, integrons, plasmids and genetic types. J Antimicrob Chemother 51: 1287-1291 [Abstract] [Full Text]  
  • Ploy, M.-C., Chainier, D., Tran Thi, N. H., Poilane, I., Cruaud, P., Denis, F., Collignon, A., Lambert, T. (2003). Integron-Associated Antibiotic Resistance in Salmonella enterica Serovar Typhi from Asia. Antimicrob. Agents Chemother. 47: 1427-1429 [Abstract] [Full Text]  
  • Lindstedt, B.-A., Heir, E., Nygard, I., Kapperud, G. (2003). Characterization of class I integrons in clinical strains of Salmonella enterica subsp. enterica serovars Typhimurium and Enteritidis from Norwegian hospitals. J Med Microbiol 52: 141-149 [Abstract] [Full Text]  
  • Soto, S. M., Lobato, M. J., Mendoza, M. C. (2003). Class 1 Integron-Borne Gene Cassettes in Multidrug-Resistant Yersinia enterocolitica Strains of Different Phenotypic and Genetic Types. Antimicrob. Agents Chemother. 47: 421-426 [Abstract] [Full Text]  
  • Guerra, B., Soto, S., Helmuth, R., Mendoza, M. C. (2002). Characterization of a Self-Transferable Plasmid from Salmonella enterica Serotype Typhimurium Clinical Isolates Carrying Two Integron-Borne Gene Cassettes Together with Virulence and Drug Resistance Genes. Antimicrob. Agents Chemother. 46: 2977-2981 [Abstract] [Full Text]  
  • Garaizar, J., Porwollik, S., Echeita, A., Rementeria, A., Herrera, S., Wong, R. M.-Y., Frye, J., Usera, M. A., McClelland, M. (2002). DNA Microarray-Based Typing of an Atypical Monophasic Salmonella enterica Serovar. J. Clin. Microbiol. 40: 2074-2078 [Abstract] [Full Text]  
  • Liebana, E., Clouting, C., Cassar, C. A., Randall, L. P., Walker, R. A., Threlfall, E. J., Clifton-Hadley, F. A., Ridley, A. M., Davies, R. H. (2002). Comparison of gyrA Mutations, Cyclohexane Resistance, and the Presence of Class I Integrons in Salmonella enterica from Farm Animals in England and Wales. J. Clin. Microbiol. 40: 1481-1486 [Abstract] [Full Text]  
  • Echeita, M. A., Herrera, S., Usera, M. A. (2001). Atypical, fljB-Negative Salmonella enterica subsp. enterica Strain of Serovar 4,5,12:i:{-} Appears To Be a Monophasic Variant of Serovar Typhimurium. J. Clin. Microbiol. 39: 2981-2983 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»