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Antimicrobial Agents and Chemotherapy, April 2001, p. 1305-1308, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1305-1308.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Multidrug Resistance Is Mediated by Large Plasmids Carrying a Class 1 Integron in the Emergent Salmonella enterica Serotype [4,5,12:i:-]

Beatriz Guerra, Sara M. Soto, Jose M. Argüelles, and M. Carmen Mendoza*

Área de Microbiología, Departamento de Biología Funcional, Universidad de Oviedo, 33006 Oviedo, Principado de Asturias, Spain

Received 7 August 2000/Returned for modification 24 October 2000/Accepted 10 January 2001

A multidrug-resistant Salmonella enterica serotype [4,5,12:i:-] clone carried a class 1 integron harboring dfrA12 and aadA2 gene cassettes and blaTEM-1, aac(3)-IV, cmlA1, and tetA genes located in large plasmids of about 140 kb (carrying spv) or 120 kb (lacking spv). Several segregants, lacking multidrug resistance, contained a plasmid smaller than the parental one and no longer hybridized with probes for the lost resistances. The genes mediating resistance to ampicillin, chloramphenicol, and tetracycline in the [4,5,12:i:-] clone are different from those found in the pentadrug-resistant serotype Typhimurium DT104 clone.


* Corresponding author. Mailing address: Área de Microbiología. Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Calle Julián Clavería 6, 33006 Oviedo, Spain. Phone: 34-985-103560. Fax: 34-985-103148. E-mail: camf{at}sauron.quimica.uniovi.es.


Antimicrobial Agents and Chemotherapy, April 2001, p. 1305-1308, Vol. 45, No. 4
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.4.1305-1308.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.



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