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Antimicrobial Agents and Chemotherapy, May 2001, p. 1511-1514, Vol. 45, No. 5
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.5.1511-1514.2001
Antibiotic Susceptibilities of Genetically
Characterized Streptococcus milleri Group Strains
Michael
Tracy,
Anna
Wanahita,
Yevgeny
Shuhatovich,
Elizabeth A.
Goldsmith,
Jill E.
Clarridge III, and
Daniel M.
Musher*
Medical and Laboratory Services, Veterans
Affairs Medical Center, and the Departments of Medicine, Molecular
Virology, and Pathology, Baylor College of Medicine, Houston, Texas
77030
Received 27 October 2000/Returned for modification 18 December
2000/Accepted 15 February 2001
Previous studies of the antibiotic susceptibility of
Streptococcus milleri group organisms have distinguished
among species by using phenotypic techniques. Using 44 isolates that
were speciated by 16S rRNA gene sequencing, we studied the MICs and
minimum bactericidal concentrations of penicillin, ampicillin,
ceftriaxone, and clindamycin for Streptococcus intermedius,
Streptococcus constellatus, and Streptococcus
anginosus. None of the organisms was resistant to beta-lactam
antibiotics, although a few isolates were intermediately resistant; one
strain of S. anginosus was tolerant to ampicillin, and
another was tolerant to ceftriaxone. Six isolates were resistant to
clindamycin, with representation from each of the three species. Relatively small differences in antibiotic susceptibilities among species of the S. milleri group show that speciation is
unlikely to be important in selecting an antibiotic to treat infection caused by one of these isolates.
*
Corresponding author. Mailing address: Infectious
Disease Section, Veterans Affairs Medical Center, Houston, TX 77030. Phone: (713) 794-7386. Fax: (713) 794-7045. E-mail:
daniel.musher{at}med.va.gov.
Antimicrobial Agents and Chemotherapy, May 2001, p. 1511-1514, Vol. 45, No. 5
0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.5.1511-1514.2001
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