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Antimicrobial Agents and Chemotherapy, May 2001, p. 1511-1514, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1511-1514.2001

Antibiotic Susceptibilities of Genetically Characterized Streptococcus milleri Group Strains

Michael Tracy, Anna Wanahita, Yevgeny Shuhatovich, Elizabeth A. Goldsmith, Jill E. Clarridge III, and Daniel M. Musher*

Medical and Laboratory Services, Veterans Affairs Medical Center, and the Departments of Medicine, Molecular Virology, and Pathology, Baylor College of Medicine, Houston, Texas 77030

Received 27 October 2000/Returned for modification 18 December 2000/Accepted 15 February 2001

Previous studies of the antibiotic susceptibility of Streptococcus milleri group organisms have distinguished among species by using phenotypic techniques. Using 44 isolates that were speciated by 16S rRNA gene sequencing, we studied the MICs and minimum bactericidal concentrations of penicillin, ampicillin, ceftriaxone, and clindamycin for Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus. None of the organisms was resistant to beta-lactam antibiotics, although a few isolates were intermediately resistant; one strain of S. anginosus was tolerant to ampicillin, and another was tolerant to ceftriaxone. Six isolates were resistant to clindamycin, with representation from each of the three species. Relatively small differences in antibiotic susceptibilities among species of the S. milleri group show that speciation is unlikely to be important in selecting an antibiotic to treat infection caused by one of these isolates.

* Corresponding author. Mailing address: Infectious Disease Section, Veterans Affairs Medical Center, Houston, TX 77030. Phone: (713) 794-7386. Fax: (713) 794-7045. E-mail: daniel.musher{at}med.va.gov.

Antimicrobial Agents and Chemotherapy, May 2001, p. 1511-1514, Vol. 45, No. 5
0066-4804/01/$04.00+0   DOI: 10.1128/AAC.45.5.1511-1514.2001


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